[HTML][HTML] Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?
TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …
and results in acute symptoms involving especially the lungs known as COVID-19. However …
[HTML][HTML] Encephalitis in patients with COVID-19: a systematic evidence-based analysis
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) predominantly
infects the respiratory system, several investigations have shown the involvement of the …
infects the respiratory system, several investigations have shown the involvement of the …
[HTML][HTML] Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID
TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …
[HTML][HTML] SARS-CoV-2 spike glycoprotein S1 induces neuroinflammation in BV-2 microglia
OA Olajide, VU Iwuanyanwu, OD Adegbola… - Molecular …, 2022 - Springer
In addition to respiratory complications produced by SARS‐CoV‐2, accumulating evidence
suggests that some neurological symptoms are associated with the disease caused by this …
suggests that some neurological symptoms are associated with the disease caused by this …
Shared genetics and causal associations between COVID‐19 and multiple sclerosis
Neuroinflammation caused by COVID‐19 negatively impacts brain metabolism and function,
while pre‐existing brain pathology may contribute to individuals' vulnerability to the adverse …
while pre‐existing brain pathology may contribute to individuals' vulnerability to the adverse …
[HTML][HTML] COVID-19 in children: expressions of type I/II/III interferons, TRIM28, SETDB1, and endogenous retroviruses in mild and severe cases
PA Tovo, S Garazzino, V Dapra, G Pruccoli… - International journal of …, 2021 - mdpi.com
Children with the new coronavirus disease 2019 (COVID-19) have milder symptoms and a
better prognosis than adult patients. Several investigations assessed type I, II, and III …
better prognosis than adult patients. Several investigations assessed type I, II, and III …
[HTML][HTML] Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions
S Liu, A Hossinger, SE Heumüller, A Hornberger… - Nature …, 2021 - nature.com
Protein aggregates associated with neurodegenerative diseases have the ability to transmit
to unaffected cells, thereby templating their own aberrant conformation onto soluble …
to unaffected cells, thereby templating their own aberrant conformation onto soluble …
[HTML][HTML] Novel scalable and simplified system to generate microglia-containing cerebral organoids from human induced pluripotent stem cells
Human cerebral organoid (CO) is a three-dimensional (3D) cell culture system that
recapitulates the developing human brain. While CO has proved an invaluable tool for …
recapitulates the developing human brain. While CO has proved an invaluable tool for …
Recombinant SARS-CoV-2 Spike Protein and its Receptor Binding Domain stimulate release of different pro-inflammatory mediators via activation of distinct receptors …
I Tsilioni, TC Theoharides - Molecular Neurobiology, 2023 - Springer
SARS-CoV-2 infects cells via its spike (S) protein binding to its surface receptor angiotensin
converting enzyme 2 (ACE2) on target cells and results in acute symptoms involving …
converting enzyme 2 (ACE2) on target cells and results in acute symptoms involving …
[HTML][HTML] Neurological update: COVID-19
AL Ren, RJ Digby, EJ Needham - Journal of neurology, 2021 - Springer
Coronavirus Disease 2019 is predominantly a disorder of the respiratory system, but
neurological complications have been recognised since early in the pandemic. The major …
neurological complications have been recognised since early in the pandemic. The major …