[HTML][HTML] Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

[HTML][HTML] Encephalitis in patients with COVID-19: a systematic evidence-based analysis

MA Islam, C Cavestro, SS Alam, S Kundu, MA Kamal… - Cells, 2022 - mdpi.com
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) predominantly
infects the respiratory system, several investigations have shown the involvement of the …

[HTML][HTML] Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

[HTML][HTML] SARS-CoV-2 spike glycoprotein S1 induces neuroinflammation in BV-2 microglia

OA Olajide, VU Iwuanyanwu, OD Adegbola… - Molecular …, 2022 - Springer
In addition to respiratory complications produced by SARS‐CoV‐2, accumulating evidence
suggests that some neurological symptoms are associated with the disease caused by this …

Shared genetics and causal associations between COVID‐19 and multiple sclerosis

A Baranova, H Cao, S Teng, KP Su… - Journal of medical …, 2023 - Wiley Online Library
Neuroinflammation caused by COVID‐19 negatively impacts brain metabolism and function,
while pre‐existing brain pathology may contribute to individuals' vulnerability to the adverse …

[HTML][HTML] COVID-19 in children: expressions of type I/II/III interferons, TRIM28, SETDB1, and endogenous retroviruses in mild and severe cases

PA Tovo, S Garazzino, V Dapra, G Pruccoli… - International journal of …, 2021 - mdpi.com
Children with the new coronavirus disease 2019 (COVID-19) have milder symptoms and a
better prognosis than adult patients. Several investigations assessed type I, II, and III …

[HTML][HTML] Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

S Liu, A Hossinger, SE Heumüller, A Hornberger… - Nature …, 2021 - nature.com
Protein aggregates associated with neurodegenerative diseases have the ability to transmit
to unaffected cells, thereby templating their own aberrant conformation onto soluble …

[HTML][HTML] Novel scalable and simplified system to generate microglia-containing cerebral organoids from human induced pluripotent stem cells

B Bodnar, Y Zhang, J Liu, Y Lin, P Wang… - Frontiers in Cellular …, 2021 - frontiersin.org
Human cerebral organoid (CO) is a three-dimensional (3D) cell culture system that
recapitulates the developing human brain. While CO has proved an invaluable tool for …

Recombinant SARS-CoV-2 Spike Protein and its Receptor Binding Domain stimulate release of different pro-inflammatory mediators via activation of distinct receptors …

I Tsilioni, TC Theoharides - Molecular Neurobiology, 2023 - Springer
SARS-CoV-2 infects cells via its spike (S) protein binding to its surface receptor angiotensin
converting enzyme 2 (ACE2) on target cells and results in acute symptoms involving …

[HTML][HTML] Neurological update: COVID-19

AL Ren, RJ Digby, EJ Needham - Journal of neurology, 2021 - Springer
Coronavirus Disease 2019 is predominantly a disorder of the respiratory system, but
neurological complications have been recognised since early in the pandemic. The major …