The peri-menopause or menopausal transition—the time period that surrounds the final
years of a woman's reproductive life—is associated with profound reproductive and …

Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is
emerging as a ubiquitous mechanism to control the properties and function of a diverse …

High-fat diet (HFD) and metabolic diseases cause detrimental effects on hippocampal
synaptic plasticity, learning, and memory through molecular mechanisms still poorly …

Many tumors are dependent on de novo fatty acid synthesis to maintain cell growth. Fatty
acid synthase (FASN) catalyzes the final synthetic step of this pathway, and its upregulation …

Protein palmitoylation, in which C16 fatty acid chains are attached to cysteine residues via a
reversible thioester linkage, is one of the most common lipid modifications and plays …

Protein S-palmitoylation is a covalent and reversible lipid modification that specifically
targets cysteine residues within many eukaryotic proteins. In mammalian cells, the …

G protein-coupled receptors (GPCRs) are a large diverse family of cell surface signaling
receptors implicated in various types of cancers. Several studies indicate that GPCRs control …

Conspectus The structural boundaries of living cells are composed of numerous membrane-
forming lipids. Lipids not only are crucial for the cellular compartmentalization but also are …

Synaptic plasticity is mediated by the dynamic localization of proteins to and from synapses.
This is controlled, in part, through activity-induced palmitoylation of synaptic proteins. Here …

The spike proteins of enveloped viruses are transmembrane glycoproteins that typically
undergo post-translational attachment of palmitate on cysteine residues on the cytoplasmic …