In accordance with the comorbidity-inflammation paradigm, comorbidities and especially
metabolic comorbidities are presumed to drive development and severity of heart failure with …

Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated
cardiomyopathy (DCM), but the underlying pathomechanisms are unclear and disease …

Randomized clinical trials initially used heart failure (HF) patients with low left ventricular
ejection fraction (LVEF) to select study populations with high risk to enhance statistical …

Das macht das Buch aus: Der „Silbernagel “, wie viele dieses Buch nennen, zeichnet sich
durch die grobe Unterteilung in die zahlreichen klar strukturierten Kapitel aus, die häufig …

Single-molecule magnetic tweezers deliver magnetic force and torque to single target
molecules, permitting the study of dynamic changes in biomolecular structures and their …

The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …

Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …

Background: Truncating variants in the Titin gene (TTNtvs) are common in individuals with
idiopathic dilated cardiomyopathy (DCM). However, a comprehensive genomics-first …

Titin has long been recognized as a mechanical protein in muscle cells that has a main
function as a molecular spring in the contractile units, the sarcomeres. Recent work suggests …