Myofibrils are the intracellular structures formed by actin and myosin filaments. They are
paracrystalline contractile cables with unusually well-defined dimensions. The sliding of …

A major cause of heart failure is cardiomyopathies, with dilated cardiomyopathy (DCM) as
the most common form. Over 40 genes are linked to DCM, among them TTN and RBM20 …

The quest for novel methods to mature human induced pluripotent stem cell-derived
cardiomyocytes (hiPSC-CMs) for cardiac regeneration, modelling and drug testing has …

The ability § of the heart to adapt to changes in the mechanical environment is critical for
normal cardiac physiology. The role of nitric oxide is increasingly recognized as a mediator …

Obscurin comprises a family of giant modular proteins that play key structural and regulatory
roles in striated muscles. Immunoglobulin domains 58/59 (Ig58/59) of obscurin mediate …

Abstract Purpose of Review Truncating TTN variants (TTN tv) are the most common genetic
cause of dilated cardiomyopathy (DCM), but the underlying mechanisms are incompletely …

Phosphorylation-dependent signal transduction plays an important role in regulating the
functions and fate of skeletal muscle cells. Central players in the phospho-signaling network …

Abstract Introduction/Aims Effective strategies for rapid recovery after surgery are needed.
Therefore, we investigated the effects of exercise prehabilitation (EP) and hindlimb …

Cardiomyocytes are the motor units that drive the contraction and relaxation of the heart.
Traditionally, testing of drugs for cardiotoxic effects has relied on primary cardiomyocytes …

The end-stage of the clinical combination of heart failure and kidney disease has become
known as cardiorenal syndrome. Adverse consequences related to diabetes …