Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention

SS Hecht, DK Hatsukami - Nature Reviews Cancer, 2022 - nature.com
Tobacco products present a deadly combination of nicotine addiction and carcinogen
exposure resulting in millions of cancer deaths per year worldwide. A plethora of smokeless …

[HTML][HTML] Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines

Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …

Dysregulation of fatty acid metabolism associated with esophageal inflammation of ICR mice induced by nitrosamines exposure

H Zhang, C Zhao, Q Liu, Y Zhang, K Luo, Y Pu… - Environmental …, 2022 - Elsevier
Nitrosamines, as ubiquitous environmental carcinogens with adverse impact on human
health, were crucial inducers of esophageal cancer (EC). Esophageal inflammation (EI) was …

Construction of anti-biofouling imprinted sorbents based on anisotropic polydopamine nanotubes for fast and selective capture of 2′-deoxyadenosine

M Li, P Wang, S Luo, Y Wu, X Tian, J Pan - Separation and Purification …, 2023 - Elsevier
Abstract Development of multifunctional sorbents with specific recognition, rapid separation
and biofouling resistance is highly desired for the biological samples full of nutrients. Herein …

Identification of an N′-Nitrosonornicotine-Specific Deoxyadenosine Adduct in Rat Liver and Lung DNA

Y Li, SS Hecht - Chemical research in toxicology, 2021 - ACS Publications
The tobacco-specific nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) are considered to be two of the most important carcinogens …

Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of N′-Nitrosonornicotine (NNN) in the Rat

Y Li, RP Dator, LA Maertens, S Balbo… - Chemical research in …, 2023 - ACS Publications
The tobacco-specific nitrosamine N′-nitrosonornicotine (NNN) and its close analogue 4-(N-
nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) are classified as “carcinogenic to …

[HTML][HTML] Multiscale computational investigations of the translesion synthesis bypass of tobacco-derived DNA adducts: critical insights that complement experimental …

KA Wilson, YER Jeong, SD Wetmore - Physical Chemistry Chemical …, 2022 - pubs.rsc.org
Among the numerous agents that damage DNA, tobacco products remain one of the most
lethal and result in the most diverse set of DNA lesions. This perspective aims to provide an …

Mass Spectrometric Quantitation of N′-Nitrosonornicotine-1N-oxide in the Urine of Cigarette Smokers and Smokeless Tobacco Users

Y Li, SS Hecht - Chemical research in toxicology, 2022 - ACS Publications
N′-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK),
which always occur together and are present exclusively in tobacco products, are classified …

Structure Elucidation and Quantitation of 11 N′-n-Acylnornicotines in Cherry-Red Tobacco

Y Li, T Pang, J Shi, G Bai, X Sui… - Journal of …, 2023 - academic.oup.com
Eleven consecutive N′-n-acylnornicotines from cherry-red tobacco were structurally
elucidated and quantitively analyzed using chromatography and mass spectrometry. All of …

The Current Status of Cigarette Smoking and Air Pollution Associated Lung Cancer

F Ma - 2022 - preprints.org
Cigarette smoking and air pollution (particulate matter) are recognized as two major
etiological factors for lung cancer. Of all the risk factors, cigarette smoking is significantly …