Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

Postoperative atrial fibrillation: mechanisms, manifestations and management

D Dobrev, M Aguilar, J Heijman, JB Guichard… - Nature Reviews …, 2019 - nature.com
Postoperative atrial fibrillation (POAF) complicates 20–40% of cardiac surgical procedures
and 10–20% of non-cardiac thoracic operations. Typical features include onset at 2–4 days …

[HTML][HTML] Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

D Dobrev, J Heijman, R Hiram, N Li… - Nature Reviews …, 2023 - nature.com
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …

Computational models of atrial fibrillation: Achievements, challenges, and perspectives for improving clinical care

J Heijman, H Sutanto, HJGM Crijns… - Cardiovascular …, 2021 - academic.oup.com
Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …

Prevention of Pathological Atrial Remodeling and Atrial Fibrillation: JACC State-of-the-Art Review

YC Chen, A Voskoboinik, AL Gerche… - Journal of the American …, 2021 - jacc.org
Atrial enlargement in response to pathological stimuli (eg, hypertension, mitral valve
disease) and physiological stimuli (exercise, pregnancy) can be comparable in magnitude …

Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review

A Ajoolabady, S Nattel, GYH Lip, J Ren - Journal of the American College …, 2022 - jacc.org
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia

LM Moreira, A Takawale, M Hulsurkar, DA Menassa… - Nature, 2020 - nature.com
Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality
and morbidity, and particularly to the risk of stroke in humans. Atrial-tissue fibrosis is a …

[HTML][HTML] The association between diabetes mellitus and atrial fibrillation: clinical and mechanistic insights

LJ Bohne, D Johnson, RA Rose, SB Wilton… - Frontiers in …, 2019 - frontiersin.org
A number of clinical studies have reported that diabetes mellitus (DM) is an independent risk
factor for Atrial fibrillation (AF). After adjustment for other known risk factors including age …

Dynamics of atrial fibrillation mechanisms and comorbidities

J Heijman, D Linz, U Schotten - Annual review of physiology, 2021 - annualreviews.org
Atrial fibrillation (AF) contributes to morbidity and mortality of millions of individuals. Its
molecular, cellular, neurohumoral, and hemodynamic pathophysiological mechanisms are …

Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation

N Li, BJJM Brundel - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia,
affects millions of people worldwide. AF is associated with common risk factors, including …