Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Direct-to-consumer (DTC) genetic tests have generated considerable scholarly attention and
public intrigue. Although the current consumer genetic testing regime relies on the reporting …

Importance Primary prevention of atherosclerotic cardiovascular disease (ASCVD) relies on
risk stratification. Genome-wide polygenic risk scores (PRSs) are proposed to improve …

Polygenic risk scores (PRS) may improve risk-stratification in preventive care. Their clinical
implementation will depend on primary care physicians'(PCPs) uptake. We surveyed PCPs …

Background State-of-the-art genetic risk interpretation for a common complex disease such
as coronary artery disease (CAD) requires assessment for both monogenic variants—such …

Considerable progress continues to be made with regards to the value and use of disease
associated polygenic scores (PGS). PGS aim to capture a person's genetic liability to a …

Coronary artery disease (CAD) remains a leading cause of morbidity and mortality
worldwide, highlighting the limitations of current primary and secondary prevention …

Polygenic risk scores (PRS) estimate genetic susceptibility of an individual to disease and
have the potential of providing utility in multiple clinical contexts. However, their …

Recent discoveries from the past 15 years of human genetic association studies have
provided new insights into the common genetic basis of coronary artery disease and its risk …