T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

CD8+ T cells are critical mediators of cytotoxic effector function in infection, cancer and
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …

CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance
mechanisms in autoreactive CD8 T cells. How autoimmune T cell populations arise and are …

Impaired chronic viral and tumor clearance has been attributed to CD8+ T cell exhaustion, a
differentiation state in which T cells have reduced and altered effector function that can be …

Motivation Immune cells are important components of the immune system and are crucial for
disease initiation, progression, prognosis and survival. Although several computational …

Immune checkpoint receptors such as programmed cell death protein 1 (PD-1), cytotoxic T-
lymphocyte associated protein 4 (CTLA-4), lymphocyte-activation gene 3 (LAG-3), and T cell …

Immune-related adverse events (irAEs) are a notable complication of PD-1 cancer
immunotherapy. A better understanding of how these iatrogenic diseases compare with …

Myocardial infarction (MI) is strongly associated with the temporal regulation of cardiac
immunity. However, a variety of current clinical trials have failed because of the lack of post …

Rationale: Evident immunosuppression has been commonly seen among septic patients,
and it is demonstrated to be a major driver of morbidity. Nevertheless, a comprehensive view …

Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …