CD8 T cells mediate a critical component of immunity against foreign pathogens,
transformed cells, and self-antigens in the settings of chronic infection, cancer, and …

The immune system is composed of many checks and balances that are critical to limiting
disease and maintaining homeostasis. T cells are critical regulators of this balance. For …

How autoimmune diseases are regulated is a long-term research topic in the autoimmunity
field. We use autoimmune diabetes as a model to study this. Autoimmune diabetes is a T cell …

Нарушения углеводного обмена представляют собой одну из важнейших
медикосоциальных проблем. Отклонения в содержании сахара в крови как в сторону …

RNA sequencing, along with single-cell RNA sequencing, has been gaining popularity in
the last decade and a half. Numerous commercial and non-commercial methods to perform …

CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance in
autoreactive CD8 T cells. However, the mechanisms by which autoimmune T cell …

Disturbing the interaction between sympathetic nerves and macrophages in islets has been
shown to protect from insulitis development. To study the intra-islet neuroimmune …

Understanding mechanisms of immune regulation is key to developing effective
immunotherapies for autoimmunity and cancer; however, many regulatory mechanisms …

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the
destruction of insulin-producing pancreatic β cells. The prevalence of T1D has significantly …

Le diabète de type 1 (DT1) est une maladie auto-immune résultant de la destruction des
cellules bêta du pancréas par des lymphocytes T (LT) auto-réactifs. L'échappement de ces …