The neuroscience of drug reward and addiction

ND Volkow, M Michaelides, R Baler - Physiological reviews, 2019 - journals.physiology.org
Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

Fractionating impulsivity: neuropsychiatric implications

JW Dalley, TW Robbins - Nature Reviews Neuroscience, 2017 - nature.com
The ability to make decisions and act quickly without hesitation can be advantageous in
many settings. However, when persistently expressed, impulsive decisions and actions are …

[HTML][HTML] Beyond stereotypes of adolescent risk taking: Placing the adolescent brain in developmental context

D Romer, VF Reyna, TD Satterthwaite - Developmental cognitive …, 2017 - Elsevier
Recent neuroscience models of adolescent brain development attribute the morbidity and
mortality of this period to structural and functional imbalances between more fully developed …

The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis

MD Scofield, JA Heinsbroek, CD Gipson… - Pharmacological …, 2016 - ASPET
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Dissecting impulsivity and its relationships to drug addictions

JD Jentsch, JR Ashenhurst… - Annals of the New …, 2014 - Wiley Online Library
Addictions are often characterized as forms of impulsive behavior. That said, it is often noted
that impulsivity is a multidimensional construct, spanning several psychological domains …

Impulsivity as a vulnerability factor for poor addiction treatment outcomes: a review of neurocognitive findings among individuals with substance use disorders

L Stevens, A Verdejo-García, AE Goudriaan… - Journal of substance …, 2014 - Elsevier
With the current review, we explore the hypothesis that individual differences in
neurocognitive aspects of impulsivity (ie, cognitive and motor disinhibition, delay discounting …

Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence

KD Ersche, A Barnes, PS Jones, S Morein-Zamir… - Brain, 2011 - academic.oup.com
A growing body of preclinical evidence indicates that addiction to cocaine is associated with
neuroadaptive changes in frontostriatal brain systems. Human studies in cocaine-dependent …

A behavioral and cognitive neuroscience perspective on impulsivity, suicide, and non-suicidal self-injury: Meta-analysis and recommendations for future research

RT Liu, ZM Trout, EM Hernandez, SM Cheek… - Neuroscience & …, 2017 - Elsevier
We conducted a meta-analysis of neurobehavioral and neurocognitive indices of impulsivity
in relation to suicidal thoughts and behaviors, as well as non-suicidal self-injury (NSSI). In …

Genome-wide association studies of impulsive personality traits (BIS-11 and UPPS-P) and drug experimentation in up to 22,861 adult research participants identify …

S Sanchez-Roige, P Fontanillas, SL Elson… - Journal of …, 2019 - Soc Neuroscience
Impulsive personality traits are complex heritable traits that are governed by frontal-
subcortical circuits and are associated with numerous neuropsychiatric disorders …

Impulsive action and impulsive choice across substance and behavioral addictions: cause or consequence?

JE Grant, SR Chamberlain - Addictive behaviors, 2014 - Elsevier
Substance use disorders are prevalent and debilitating. Certain behavioral syndromes
('behavioral addictions') characterized by repetitive habits, such as gambling disorder …