Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Q Tuo, S Zhang, P Lei - Medicinal research reviews, 2022 - Wiley Online Library
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

[HTML][HTML] The role of immune cells in post-stroke angiogenesis and neuronal remodeling: the known and the unknown

Y Ma, S Yang, Q He, D Zhang, J Chang - Frontiers in immunology, 2021 - frontiersin.org
Following a cerebral ischemic event, substantial alterations in both cellular and molecular
activities occur due to ischemia-induced cerebral pathology. Mounting evidence indicates …

[HTML][HTML] Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury

L Wu, X Xiong, X Wu, Y Ye, Z Jian, Z Zhi… - Frontiers in molecular …, 2020 - frontiersin.org
The cerebral ischemia injury can result in neuronal death and/or functional impairment,
which leads to further damage and dysfunction after recovery of blood supply. Cerebral …

CXCR2 receptor: regulation of expression, signal transduction, and involvement in cancer

J Korbecki, P Kupnicka, M Chlubek, J Gorący… - International Journal of …, 2022 - mdpi.com
Chemokines are a group of about 50 chemotactic cytokines crucial for the migration of
immune system cells and tumor cells, as well as for metastasis. One of the 20 chemokine …

Bioinformatics analysis of prognostic miRNA signature and potential critical genes in colon cancer

W Chen, C Gao, Y Liu, Y Wen, X Hong… - Frontiers in Genetics, 2020 - frontiersin.org
This study aims to lay a foundation for studying the regulation of microRNAs (miRNAs) in
colon cancer by applying bioinformatics methods to identify miRNAs and their potential …

[HTML][HTML] Key phytochemicals and biological functions of chuanxiong rhizoma against ischemic stroke: a network pharmacology and experimental assessment

P Zeng, Y Yi, HF Su, CY Ye, YW Sun… - Frontiers in …, 2021 - frontiersin.org
Presently, the treatment options for ischemic stroke (IS) are limited due to the complicated
pathological process of the disease. Chuanxiong Rhizome (CR), also known as …

[HTML][HTML] NK cells in cerebral ischemia

C Chen, QD Ai, SF Chu, Z Zhang, NH Chen - Biomedicine & …, 2019 - Elsevier
As a vital cell type in immune system and infiltrating cells in ischemic brain, NK cells can
bridge the crosstalk between immune system and nervous system in stroke setting. The …

IL-8 exacerbates CCl4-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway

Y Ma, Y Bao, L Wu, Y Ke, L Tan, H Ren, J Song… - Molecular …, 2022 - Elsevier
Liver fibrosis is an excessive accumulation of extracellular matrix (ECM) due to chronic liver
injury. In recent years, the mechanism of liver fibrosis has been extensively studied. Hepatic …

Exploring the hub mechanisms of ischemic stroke based on protein-protein interaction networks related to ischemic stroke and inflammatory bowel disease

W Hu, P Li, N Zeng, S Tan - Scientific Reports, 2023 - nature.com
Ischemic stroke is highly concerning because it often leads to severe long-term neurological
disability. Among clinical trials, ischemic stroke and inflammatory bowel disease interactions …

Current approaches and future perspectives for nanobodies in stroke diagnostic and therapy

L Jank, C Pinto-Espinoza, Y Duan, F Koch-Nolte… - Antibodies, 2019 - mdpi.com
Antibody-based biologics are the corner stone of modern immunomodulatory therapy.
Though highly effective in dampening systemic inflammatory processes, their large size and …