Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is an important neurotransmitter, that
activates the largest subtype family of G-protein-coupled receptors. Drugs that target 5 …

5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous
system and peripheral structures, acting also as a hormone in platelets. Although its …

Social play behaviour is a highly energetic and rewarding activity that is of great importance
for the development of brain and behaviour. Social play is abundant during the juvenile and …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains
circadian rhythms by synchronization to environmental cues and is involved in diverse …

Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The
effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as …

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder in which recurrent
abdominal pain is associated with defecation or a change in bowel habits (constipation …