An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …
effectiveness, ease of administration, and high patient compliance. However, the absorption …
[HTML][HTML] Necrotizing enterocolitis: Bench to bedside approaches and advancing our understanding of disease pathogenesis
DK Singh, CM Miller, KA Orgel, M Dave… - Frontiers in …, 2023 - frontiersin.org
Necrotizing enterocolitis (NEC) is a devastating, multifactorial disease mainly affecting the
intestine of premature infants. Recent discoveries have significantly enhanced our …
intestine of premature infants. Recent discoveries have significantly enhanced our …
[HTML][HTML] Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract (GIT).
Cigarette smoke (CS) exposure and chronic obstructive pulmonary disease (COPD) are risk …
Cigarette smoke (CS) exposure and chronic obstructive pulmonary disease (COPD) are risk …
[HTML][HTML] Treatment with Ligilactobacillus murinus lowers blood pressure and intestinal permeability in spontaneously hypertensive rats
M Mukohda, T Yano, T Matsui, S Nakamura… - Scientific Reports, 2023 - nature.com
One feature of hypertension is a microbial imbalance with increased intestinal permeability.
In this study, we examined whether an alteration in the microbiota affects blood pressure …
In this study, we examined whether an alteration in the microbiota affects blood pressure …
[HTML][HTML] In vitro models and ex vivo systems used in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal condition.
Ulcerative colitis and Crohn's disease are types of inflammatory bowel disease. Over many …
Ulcerative colitis and Crohn's disease are types of inflammatory bowel disease. Over many …
[HTML][HTML] Investigating gut permeability in animal models of disease
M González-González, C Díaz-Zepeda… - Frontiers in …, 2019 - frontiersin.org
A growing number of investigations report the association between gut permeability and
intestinal or extra-intestinal disorders under the basis that translocation of gut luminal …
intestinal or extra-intestinal disorders under the basis that translocation of gut luminal …
[HTML][HTML] Comparison of the effects of the intestinal permeation enhancers, SNAC and sodium caprate (C10): Isolated rat intestinal mucosae and sacs
C Twarog, F McCartney, SM Harrison, B Illel… - European Journal of …, 2021 - Elsevier
SNAC and C 10 are intestinal permeation enhancers (PEs) used in formulations of peptides
for oral delivery in clinical trials. Our aims were to compare their:(i) mechanism of action in …
for oral delivery in clinical trials. Our aims were to compare their:(i) mechanism of action in …
[HTML][HTML] Ribociclib hybrid lipid–polymer nanoparticle preparation and characterization for cancer treatment
Ribociclib is a newly approved orally administered drug for breast cancer. This study aimed
to prepare, characterize, and evaluate hybrid lipid–polymer nanoparticles (PLNs) of …
to prepare, characterize, and evaluate hybrid lipid–polymer nanoparticles (PLNs) of …
Glycated milk protein fermented with Lactobacillus rhamnosus ameliorates the cognitive health of mice under mild-stress condition
This study aimed to investigate the effects of glycated milk casein (Gc) fermented with
Lactobacillus rhamnosus 4B15 (FGc) on the intestinal microbiota and physiological and …
Lactobacillus rhamnosus 4B15 (FGc) on the intestinal microbiota and physiological and …
[HTML][HTML] Challenges and Opportunities in the Oral Delivery of Recombinant Biologics
S Masloh, M Culot, F Gosselet, A Chevrel, L Scapozza… - Pharmaceutics, 2023 - mdpi.com
Recombinant biological molecules are at the cutting-edge of biomedical research thanks to
the significant progress made in biotechnology and a better understanding of subcellular …
the significant progress made in biotechnology and a better understanding of subcellular …