An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Y Xu, N Shrestha, V Préat, A Beloqui - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

[HTML][HTML] Necrotizing enterocolitis: Bench to bedside approaches and advancing our understanding of disease pathogenesis

DK Singh, CM Miller, KA Orgel, M Dave… - Frontiers in …, 2023 - frontiersin.org
Necrotizing enterocolitis (NEC) is a devastating, multifactorial disease mainly affecting the
intestine of premature infants. Recent discoveries have significantly enhanced our …

[HTML][HTML] Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction

M Fricker, BJ Goggins, S Mateer, B Jones, RY Kim… - JCI insight, 2018 - ncbi.nlm.nih.gov
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract (GIT).
Cigarette smoke (CS) exposure and chronic obstructive pulmonary disease (COPD) are risk …

[HTML][HTML] Treatment with Ligilactobacillus murinus lowers blood pressure and intestinal permeability in spontaneously hypertensive rats

M Mukohda, T Yano, T Matsui, S Nakamura… - Scientific Reports, 2023 - nature.com
One feature of hypertension is a microbial imbalance with increased intestinal permeability.
In this study, we examined whether an alteration in the microbiota affects blood pressure …

[HTML][HTML] In vitro models and ex vivo systems used in inflammatory bowel disease

A Joshi, A Soni, S Acharya - In vitro models, 2022 - Springer
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal condition.
Ulcerative colitis and Crohn's disease are types of inflammatory bowel disease. Over many …

[HTML][HTML] Investigating gut permeability in animal models of disease

M González-González, C Díaz-Zepeda… - Frontiers in …, 2019 - frontiersin.org
A growing number of investigations report the association between gut permeability and
intestinal or extra-intestinal disorders under the basis that translocation of gut luminal …

[HTML][HTML] Comparison of the effects of the intestinal permeation enhancers, SNAC and sodium caprate (C10): Isolated rat intestinal mucosae and sacs

C Twarog, F McCartney, SM Harrison, B Illel… - European Journal of …, 2021 - Elsevier
SNAC and C 10 are intestinal permeation enhancers (PEs) used in formulations of peptides
for oral delivery in clinical trials. Our aims were to compare their:(i) mechanism of action in …

[HTML][HTML] Ribociclib hybrid lipid–polymer nanoparticle preparation and characterization for cancer treatment

R Al-Shdefat, M Hailat, OY Alshogran, W Abu Dayyih… - Polymers, 2023 - mdpi.com
Ribociclib is a newly approved orally administered drug for breast cancer. This study aimed
to prepare, characterize, and evaluate hybrid lipid–polymer nanoparticles (PLNs) of …

Glycated milk protein fermented with Lactobacillus rhamnosus ameliorates the cognitive health of mice under mild-stress condition

NS Oh, JY Joung, JY Lee, JG Song, S Oh, Y Kim… - Gut …, 2020 - Taylor & Francis
This study aimed to investigate the effects of glycated milk casein (Gc) fermented with
Lactobacillus rhamnosus 4B15 (FGc) on the intestinal microbiota and physiological and …

[HTML][HTML] Challenges and Opportunities in the Oral Delivery of Recombinant Biologics

S Masloh, M Culot, F Gosselet, A Chevrel, L Scapozza… - Pharmaceutics, 2023 - mdpi.com
Recombinant biological molecules are at the cutting-edge of biomedical research thanks to
the significant progress made in biotechnology and a better understanding of subcellular …