Computational methods and tools in antimicrobial peptide research

PGA Aronica, LM Reid, N Desai, J Li… - Journal of Chemical …, 2021 - ACS Publications
The evolution of antibiotic-resistant bacteria is an ongoing and troubling development that
has increased the number of diseases and infections that risk going untreated. There is an …

sAMPpred-GAT: prediction of antimicrobial peptide by graph attention network and predicted peptide structure

K Yan, H Lv, Y Guo, W Peng, B Liu - Bioinformatics, 2023 - academic.oup.com
Abstract Motivation Antimicrobial peptides (AMPs) are essential components of therapeutic
peptides for innate immunity. Researchers have developed several computational methods …

Antimicrobial and amyloidogenic activity of peptides. Can antimicrobial peptides be used against SARS-CoV-2?

SR Kurpe, SY Grishin, AK Surin, AV Panfilov… - International Journal of …, 2020 - mdpi.com
At present, much attention is paid to the use of antimicrobial peptides (AMPs) of natural and
artificial origin to combat pathogens. AMPs have several points that determine their …

dbAMP 2.0: updated resource for antimicrobial peptides with an enhanced scanning method for genomic and proteomic data

JH Jhong, L Yao, Y Pang, Z Li, CR Chung… - Nucleic acids …, 2022 - academic.oup.com
The last 18 months, or more, have seen a profound shift in our global experience, with many
of us navigating a once-in-100-year pandemic. To date, COVID-19 remains a life …

Anticancer peptides prediction with deep representation learning features

Z Lv, F Cui, Q Zou, L Zhang, L Xu - Briefings in bioinformatics, 2021 - academic.oup.com
Anticancer peptides constitute one of the most promising therapeutic agents for combating
common human cancers. Using wet experiments to verify whether a peptide displays …

Comprehensive assessment of machine learning-based methods for predicting antimicrobial peptides

J Xu, F Li, A Leier, D Xiang, HH Shen… - Briefings in …, 2021 - academic.oup.com
Antimicrobial peptides (AMPs) are a unique and diverse group of molecules that play a
crucial role in a myriad of biological processes and cellular functions. AMP-related studies …

Machine learning prediction of antimicrobial peptides

G Wang, II Vaisman, ML van Hoek - Computational peptide science …, 2022 - Springer
Antibiotic resistance constitutes a global threat and could lead to a future pandemic. One
strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial …

dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications

Z Li, S Li, M Luo, JH Jhong, W Li, L Yao… - Nucleic acids …, 2022 - academic.oup.com
Protein post-translational modifications (PTMs) play an important role in different cellular
processes. In view of the importance of PTMs in cellular functions and the massive data …

iAMPCN: a deep-learning approach for identifying antimicrobial peptides and their functional activities

J Xu, F Li, C Li, X Guo, C Landersdorfer… - Briefings in …, 2023 - academic.oup.com
Antimicrobial peptides (AMPs) are short peptides that play crucial roles in diverse biological
processes and have various functional activities against target organisms. Due to the abuse …

Deep-ABPpred: identifying antibacterial peptides in protein sequences using bidirectional LSTM with word2vec

R Sharma, S Shrivastava, S Kumar Singh… - Briefings in …, 2021 - academic.oup.com
The overuse of antibiotics has led to emergence of antimicrobial resistance, and as a result,
antibacterial peptides (ABPs) are receiving significant attention as an alternative …