Inflammatory cytokines in atherosclerosis: current therapeutic approaches

D Tousoulis, E Oikonomou, EK Economou… - European heart …, 2016 - academic.oup.com
The notion of atherosclerosis as a chronic inflammatory disease has intensified research on
the role of cytokines and the way these molecules act and interact to initiate and sustain …

[HTML][HTML] The updated NICE guidelines: cardiac CT as the first-line test for coronary artery disease

AJ Moss, MC Williams, DE Newby, ED Nicol - Current cardiovascular …, 2017 - Springer
Abstract Purpose of Review Cost-effective care pathways are integral to delivering
sustainable healthcare programmes. Due to the overestimation of coronary artery disease …

Impact of plaque burden versus stenosis on ischemic events in patients with coronary atherosclerosis

MB Mortensen, O Dzaye, FH Steffensen… - Journal of the American …, 2020 - jacc.org
Background Patients with obstructive coronary artery disease (CAD) are at high risk for
cardiovascular disease (CVD) events. However, it remains unclear whether the high risk is …

Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society …

RD Santos, SS Gidding, RA Hegele… - The lancet Diabetes & …, 2016 - thelancet.com
Familial hypercholesterolaemia is common in individuals who had a myocardial infarction at
a young age. As many as one in 200 people could have heterozygous familial …

Use of coronary computed tomographic angiography to guide management of patients with coronary disease

MC Williams, A Hunter, ASV Shah, V Assi… - Journal of the American …, 2016 - jacc.org
Background: In a prospective, multicenter, randomized controlled trial, 4,146 patients were
randomized to receive standard care or standard care plus coronary computed tomography …

Challenges and opportunities for the prevention and treatment of cardiovascular disease among young adults: report from a National Heart, Lung, and Blood Institute …

HC Gooding, SS Gidding, AE Moran… - Journal of the …, 2020 - Am Heart Assoc
Improvements in cardiovascular disease (CVD) rates among young adults in the past 2
decades have been offset by increasing racial/ethnic and gender disparities, persistence of …

Excess cardiovascular risk in women relative to men referred for coronary angiography is associated with severely impaired coronary flow reserve, not obstructive …

VR Taqueti, LJ Shaw, NR Cook, VL Murthy, NR Shah… - Circulation, 2017 - Am Heart Assoc
Background: Cardiovascular disease (CVD) fatality rates are higher for women than for men,
yet obstructive coronary artery disease (CAD) is less prevalent in women. Coronary flow …

Prognostic implications of plaque characteristics and stenosis severity in patients with coronary artery disease

JM Lee, KH Choi, BK Koo, J Park, J Kim… - Journal of the American …, 2019 - jacc.org
Background: Although the presence of ischemia is a key prognostic factor in patients with
coronary artery disease, the presence of high-risk plaque characteristics (HRPC) is also …

Ischemia and no obstructive coronary artery disease (INOCA): what is the risk?

R Herscovici, T Sedlak, J Wei, CJ Pepine… - Journal of the …, 2018 - Am Heart Assoc
An increasing number of stable patients with evidence of ischemia but no obstructive
coronary artery disease (CAD) at coronary angiography, now termed INOCA, are seen …

Clinical outcomes after evaluation of stable chest pain by coronary computed tomographic angiography versus usual care: a meta-analysis

MS Bittencourt, EA Hulten, VL Murthy… - Circulation …, 2016 - Am Heart Assoc
Background—Limited data exist on how noninvasive testing options compare for evaluating
patients with suspected stable coronary artery disease. In this study, we have performed a …