The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases
M Piotrowska, M Swierczynski, J Fichna… - Pharmacological …, 2021 - Elsevier
Abstract Nrf2 (nuclear factor erythroid 2-related factor 2) is a stress-responsive transcription
factor, associated with cellular homeostasis. Under normal conditions Nrf2 is kept in the …
factor, associated with cellular homeostasis. Under normal conditions Nrf2 is kept in the …
Phytochemicals and regulation of NF-kB in inflammatory bowel diseases: an overview of in vitro and in vivo effects
LF Laurindo, ARO Santos, ACA Carvalho, MD Bechara… - Metabolites, 2023 - mdpi.com
Inflammatory bowel diseases (IBD) are chronic relapsing idiopathic inflammatory conditions
affecting the gastrointestinal tract. They are mainly represented by two forms, ulcerative …
affecting the gastrointestinal tract. They are mainly represented by two forms, ulcerative …
[HTML][HTML] Mo3Se4 nanoparticle with ROS scavenging and multi-enzyme activity for the treatment of DSS-induced colitis in mice
H Guo, H Guo, Y Xie, Y Chen, C Lu, Z Yang, Y Zhu… - Redox biology, 2022 - Elsevier
Ulcerative colitis (UC), as a most common inflammatory bowel disease (IBD), has become a
global public health concern. Exploring novel method of treating UC is urgent and …
global public health concern. Exploring novel method of treating UC is urgent and …
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway
T Xiong, X Zheng, K Zhang, H Wu, Y Dong… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Ulcerative colitis (UC) is a chronic inflammatory bowel
disease (IBD), that is associated with a significantly increased risk of colon cancer. As a …
disease (IBD), that is associated with a significantly increased risk of colon cancer. As a …
Recent advances in understanding Nrf2 agonism and its potential clinical application to metabolic and inflammatory diseases
Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …
Lactobacillus plantarum HNU082 alleviates dextran sulfate sodium-induced ulcerative colitis in mice through regulating gut microbiome
Probiotics have shown good efficacy in the prevention of ulcerative colitis (UC), but the
specific mechanism remains unclear. Therefore, shotgun metagenomic and transcriptome …
specific mechanism remains unclear. Therefore, shotgun metagenomic and transcriptome …
Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response
W Yang, K Tao, P Zhang, X Chen, X Sun, R Li - Biochemical Pharmacology, 2022 - Elsevier
Background Acute liver injury (ALI) caused by sepsis is a fearful disease with high mortality
and poor prognosis. This study aimed to explore the roles and mechanism of Maresin 1 …
and poor prognosis. This study aimed to explore the roles and mechanism of Maresin 1 …
Targeting NRF2–KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases
The transcription factor NRF2 and its endogenous inhibitor KEAP1 play a crucial role in the
maintenance of cellular redox homeostasis by regulating the gene expression of diverse …
maintenance of cellular redox homeostasis by regulating the gene expression of diverse …
Canna x generalis LH Bailey rhizome extract ameliorates dextran sulfate sodium-induced colitis via modulating intestinal mucosal dysfunction, oxidative stress …
TN Mahmoud, WH El-Maadawy, ZA Kandil… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Genus Canna is used in folk medicine as
demulcent, diaphoretic, antipyretic, mild laxative and in gastrointestinal upsets therapy …
demulcent, diaphoretic, antipyretic, mild laxative and in gastrointestinal upsets therapy …
[HTML][HTML] Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2 …
W Zhang, W Wang, C Shen, X Wang, Z Pu… - Aging (Albany NY …, 2021 - ncbi.nlm.nih.gov
Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial
cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome - PMC …
cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome - PMC …