Inflammatory responses in the peripheral (PNS) and central nervous systems (CNS) play
key roles in the development and persistence of many pathologic pain states. 1 Certain …

Pain of the orofacial region is the primary complaint for which patients seek treatment. Of all
the orofacial pain conditions, one condition that possess a significant global health problem …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

Many orofacial pain conditions involve inflammation of orofacial tissues and they range from
acute pulpitis (toothache) and mucositis to chronic arthritic conditions affecting the …

A still commonly held view in the literature and clinical practice is that bruxism causes pain
because of overloading of the musculoskeletal tissue and craniofacial pain, on the other …

summary This article provides a review of somatosensory and motor pathways and
processes involved in oral sensorimotor function and dysfunction. It reviews somatosensory …

The specific functions of sensory systems depend on the tissue-specific expression of genes
that code for molecular sensor proteins that are necessary for stimulus detection and …

Temporomandibular joint disorders (TMDs) are a prevalent disease covering pain and
dysfunction of temporomandibular joints and masticatory muscles, which can be detrimental …

Abstract Ethnopharmacological relevance Stachys lavandulifolia Vahl (Lamiaceae) is a
medicinal plant widely used in Turkey and Iranian folk medicine due to its analgesic and anti …

Aims: To evaluate the antinociceptive effects of citronellal (CTL) on formalin-, capsaicin-, and
glutamate-induced orofacial nociception in mice and to investigate whether such effects …