Among the various dosage forms, oral medicine has extensive benefits including ease of
administration and patients' compliance, over injectable, suppositories, ocular and nasal …

Thrombosis has threatened human health in past decades. Bacillus nattokinase is a
potential low-cost thrombolytic drug without side-effects and has been introduced into the …

Nattokinase (NK), a protease enzyme produced by Bacillus subtilis, has various biological
effects such as lipid-lowering activity, antihypertensive, antiplatelet/anticoagulant, and …

With the dramatic increase in mortality of cardiovascular diseases (CVDs) caused by
thrombus, this has sparked an interest in seeking more effective thrombolytic drugs or …

Nattokinase is a thrombolytic drug that is more advantageous than urokinase, streptokinase,
and tissue plasminogen activator because of its low price, high efficiency, and nontoxic side …

Abstract According to the World Health Organization, cardiovascular disease (CVD) has
become a major cause of chronic illness around the globe. It has been reported that soy …

Nattokinase is a potential new thrombolytic drug because of its strong thrombolytic effect,
high safety, and low cost. However, there is no research reporting on bile salt-tolerant …

Bacillus subtilis is a generally recognized as safe probiotic, which is used as a starter for
natto fermentation. Natto is a functional food with antithrombus function due to nattokinase …

In light of escalating biomedical demands across diverse diseases, there arises a pressing
need for the development of sophisticated biocompatible materials exhibiting augmented …

Ophiopogon japonicus polysaccharides (OJPs) have great anti-inflammation and
immunomodulatory abilities. However, the low bioavailability of OJPs reduces its …