Genetics and neurobiology of eating disorders

CM Bulik, JRI Coleman, JA Hardaway… - Nature …, 2022 - nature.com
Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …

[HTML][HTML] Eating disorders, heredity and environmental activation: getting epigenetic concepts into practice

H Steiger, L Booij - Journal of clinical medicine, 2020 - mdpi.com
Epigenetic mechanisms are believed to link environmental exposures to alterations in gene
expression, and in so doing, to provide a physical substrate for the activation of hereditary …

[HTML][HTML] Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

A Gialluisi, TFM Andlauer, N Mirza-Schreiber… - Molecular …, 2021 - nature.com
Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a
heritability of 40–60%. A notable part of this heritability remains unexplained, and large …

Immunoinflammatory processes: Overlapping mechanisms between obesity and eating disorders?

E Breton, JF Soh, L Booij - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Obesity and eating disorders are conditions that involve eating behaviors and are
sometimes comorbid. Current evidence supports alterations in immunoinflammatory …

Genetic risk factors for eating disorders: an update and insights into pathophysiology

H Himmerich, J Bentley, C Kan… - Therapeutic advances …, 2019 - journals.sagepub.com
Genome-wide-association studies (GWASs), epigenetic, gene-expression and gene–gene
interaction projects, nutritional genomics and investigations of the gut microbiota have …

[HTML][HTML] What next for eating disorder genetics? Replacing myths with facts to sharpen our understanding

LM Huckins, R Signer, J Johnson, YK Wu… - Molecular …, 2022 - nature.com
Substantial progress has been made in the understanding of anorexia nervosa (AN) and
eating disorder (ED) genetics through the efforts of large-scale collaborative consortia …

Genetics of anorexia nervosa

JH Baker, K Schaumberg, MA Munn-Chernoff - Current psychiatry reports, 2017 - Springer
Abstract Purpose of Review Genetic factors contribute to the etiology of anorexia nervosa
(AN). This review synthesizes the current state of knowledge about the genetic etiology of …

[HTML][HTML] Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma

E Hymel, KW Fisher, PA Farazi - BMC cancer, 2022 - Springer
Background Nonalcoholic fatty liver disease affects about 24% of the world's population and
may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular …

[HTML][HTML] SIRT1 accelerates the progression of activity-based anorexia

TM Robinette, JW Nicholatos, AB Francisco… - Nature …, 2020 - nature.com
Food consumption is fundamental for life, and eating disorders often result in devastating or
life-threatening conditions. Anorexia nervosa (AN) is characterized by a persistent restriction …

A metabolic perspective on reward abnormalities in anorexia nervosa

P Duriez, N Ramoz, P Gorwood, O Viltart… - Trends in Endocrinology & …, 2019 - cell.com
Anorexia nervosa (AN) is the psychiatric disorder with the highest mortality rate; however,
the mechanisms responsible for its pathogenesis remain largely unknown. Large-scale …