Telomerase, an enzyme responsible for the synthesis of telomeres, is activated in many
cancer cells and is involved in the maintenance of telomeres. The activity of telomerase …

Telomeres are the ends of linear chromosomes comprised of repetitive nucleotide
sequences in humans. Telomeres preserve chromosomal stability and genomic integrity …

Throughout the past 3 decades, along with the recognition that the immune system not only
influences oncogenesis and tumor progression, but also determines how established …

Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of
malignant tumours typically caused by alcohol and tobacco consumption, although an …

Understanding the basis of a successful clinical response after treatment with therapeutic
cancer vaccines is essential for the development of more efficacious therapy. After …

MHC class II tetramers have emerged as an important tool for characterization of the
specificity and phenotype of CD4 T cell immune responses, useful in a large variety of …

Telomerase is a reverse transcriptase that maintains telomeres length, compensating for the
attrition of chromosomal ends that occurs during each replication cycle. Telomerase is …

Telomeres are protective chromosomal ends that shield the chromosomes from DNA
damage, exonucleolytic degradation, recombination, and end-to-end fusion. Telomerase is …

Pancreatic adenocarcinoma is the fourth leading cause of cancer death with an overall 5-
year survival of less than 5%. As there is ample evidence that pancreatic adenocarcinomas …

Dendritic cells (DC) play a crucial role in the induction of an effective antitumor immune
response. Cytokine-induced killer (CIK) cells, a subset of T lymphocytes, have the capacity …