Elevated impulsivity is a symptom shared by various psychiatric disorders such as
substance use disorder, bipolar disorder, and attention-deficit/hyperactivity disorder …

Metabotropic glutamate (mGlu) receptors, a family of G-protein-coupled receptors, have
been identified as novel therapeutic targets based on extensive research supporting their …

Behavioural disinhibition is a common feature of the syndromes associated with
frontotemporal lobar degeneration (FTLD). It is associated with high morbidity and lacks …

There are currently no evidence-based treatment recommendations for impulse control
disorders, which include intermittent explosive disorder (IED), kleptomania and pyromania …

Gamma-aminobutyric acid (GABA) signaling plays a crucial role in drug reward and the
development of addiction. Historically, GABA neurochemistry in humans has been difficult to …

Abstract Proton (1 H) Magnetic Resonance Spectroscopy (MRS) is a non-invasive tool
capable of quantifying brain metabolite concentrations in vivo. Prioritization of …

Drug compulsion manifests in some but not all individuals and implicates multifaceted
processes including failures in top‐down cognitive control as drivers for the hazardous …

Contextual triggers are significant factors contributing to relapse in substance use disorders
(SUD). Emerging evidence points to a critical role of extracellular matrix (ECM) molecules as …

Evidence of central nervous system (CNS) exogenous opioid effects in humans has been
primarily gained through neuroimaging of three participant populations: individuals after …

Animal studies have reported the brain glutamatergic dysfunction in substance dependence.
However, proton magnetic resonance spectroscopy (1 H-MRS) studies of glutamate in …