Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies

P Sharma, P Srivastava, A Seth, PN Tripathi… - Progress in …, 2019 - Elsevier
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Therapies for prevention and treatment of Alzheimer's disease

J Mendiola-Precoma, LC Berumen… - BioMed research …, 2016 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia associated with a
progressive neurodegenerative disorder, with a prevalence of 44 million people throughout …

Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs

S Thakral, A Yadav, V Singh, M Kumar, P Kumar… - Ageing Research …, 2023 - Elsevier
Abstract Alzheimer's disease (AD), also called senile dementia, is the most common
neurological disorder. Around 50 million people, mostly of advanced age, are suffering from …

Pathophysiological aspects and therapeutic armamentarium of Alzheimer's disease: recent trends and future development

BP Dave, YB Shah, KG Maheshwari… - Cellular and Molecular …, 2023 - Springer
Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …

Structural Modification, In Vitro, In Vivo, Ex Vivo, and In Silico Exploration of Pyrimidine and Pyrrolidine Cores for Targeting Enzymes Associated with …

MA Javed, N Ashraf, M Saeed Jan… - ACS Chemical …, 2021 - ACS Publications
To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX,
acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation …

Royal jelly as an intelligent anti-aging agent—A focus on cognitive aging and Alzheimer's disease: A review

AM Ali, H Kunugi - Antioxidants, 2020 - mdpi.com
The astronomical increase of the world's aged population is associated with the increased
prevalence of neurodegenerative diseases, heightened disability, and extremely high costs …

Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery

S Kumari, K Maddeboina, RD Bachu, SHS Boddu… - Drug Discovery …, 2022 - Elsevier
Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …

Muscarinic and nicotinic acetylcholine receptor agonists: current scenario in Alzheimer's disease therapy

S Verma, A Kumar, T Tripathi… - Journal of Pharmacy and …, 2018 - academic.oup.com
Objectives Alzheimer's disease (AD) has become the primary cause of dementia. It shows a
progressive cognitive dysfunction with degenerating neurons. Acetylcholine receptors …

Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer's disease: A review

Y Jiang, H Gao, G Turdu - Bioorganic chemistry, 2017 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting 25 million
people worldwide, and cholinergic hypothesis is considered as an important hypotheses in …

Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase

ED AlFadly, PA Elzahhar, A Tramarin, S Elkazaz… - European journal of …, 2019 - Elsevier
Neuroinflammation and cholinergic deficit are key detrimental processes involved in
Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the …