Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S-and M-phases
of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is …

Cancer is a disorder that rigorously affects the human population worldwide. There is a
steady demand for new remedies to both treat and prevent this life-threatening sickness due …

Molecular glue degraders are an effective therapeutic modality, but their design principles
are not well understood. Recently, several unexpectedly diverse compounds were reported …

Several families of protein kinases orchestrate the complex events that drive the cell cycle,
and their activity is frequently deregulated in hyperproliferative cancer cells. Although …

Abstract Roscovitine [CY-202,(R)-Roscovitine, Seliciclib] is a small molecule that inhibits
cyclin-dependent kinases (CDKs) through direct competition at the ATP-binding site. It is a …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Cyclin-dependent kinase-2 (CDK2) is a member of protein kinase family. It plays an
important role in regulating various events of eukaryotic cell division cycle. Accumulated …

This review covering literature reports from the beginning of this century to 2016 describes
the synthetic pathways, the antitumor activity, the structure-activity relationship and …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a member of an
evolutionarily conserved family of protein kinases that belongs to the CMGC group of …

Cell cycle progression through each phase is regulated by heterodimers formed by cyclin-
dependent kinases (CDKs) and their regulatory partner proteins, the cyclins. Together they …