Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

Ovarian fibrosis is a pathological condition associated with aging and is responsible for a
variety of ovarian dysfunctions. Given the known contributions of tissue fibrosis to …

Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

In a society where women often want successful careers and equal opportunities to men, the
early nature of ovarian aging often forces women to make difficult life choices between …

The mitochondrial DNA (mtDNA) m. 3243A> G mutation is one of the most common
pathogenic mtDNA variants, showing complex genetics, pathogenic molecular mechanisms …

Mitochondria are indispensable for energy metabolism and cell signaling. Mitochondrial
homeostasis is sustained with stabilization of mitochondrial membrane potential, balance of …

Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

STUDY QUESTION Are human ovarian aging and the age-related female fertility decline
caused by oxidative stress and mitochondrial dysfunction in oocytes? SUMMARY ANSWER …