Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy

Z Jin, Q Gao, K Wu, J Ouyang, W Guo… - Advanced Drug Delivery …, 2023 - Elsevier
The lack of effective treatments for pulmonary diseases presents a significant global health
burden, primarily due to the challenges posed by the pulmonary barrier that hinders drug …

Oral nanomedicine: challenges and opportunities

B Deng, S Liu, Y Wang, B Ali, N Kong, T Xie… - Advanced …, 2024 - Wiley Online Library
Compared to injection administration, oral administration is free of discomfort, wound
infection, and complications and has a higher compliance rate for patients with diverse …

Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota

J Ouyang, B Deng, B Zou, Y Li, Q Bu… - Journal of the …, 2023 - ACS Publications
Selenoprotein plays a crucial role in immune cells and inflammatory regulation. However, as
a protein drug that is easily denatured or degraded in the acidic environment of the stomach …

Ultrarapid‐Acting Microneedles for Immediate Delivery of Biotherapeutics

J You, C Yang, J Han, H Wang, W Zhang… - Advanced …, 2023 - Wiley Online Library
Subcutaneous (SC) injection is a common administration route for rapid and efficient
delivery of biotherapeutics. However, syringe‐based injections usually require professional …

Inorganic nanosheet-shielded probiotics: a self-adaptable oral delivery system for intestinal disease treatment

YX Zhu, Y You, Z Chen, D Xu, W Yue, X Ma, J Jiang… - Nano Letters, 2023 - ACS Publications
The oral delivery of probiotics is commonly adopted for intestinal disease treatments in
clinical settings; however, the probiotics suffer from a strong acidic attack in the gastric area …

[HTML][HTML] Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy

YB Miao, T Xu, Y Gong, A Chen, L Zou, T Jiang… - Journal of …, 2023 - Springer
Oral administration is preferred over other drug delivery methods due to its safety, high
patient compliance, ease of ingestion without discomfort, and tolerance of a wide range of …

Recent progress of micro/nanomotors to overcome physiological barriers in the gastrointestinal tract

S Zhang, C Zhu, W Huang, H Liu, M Yang… - Journal of Controlled …, 2023 - Elsevier
Oral administration is a convenient administration route for gastrointestinal disease therapy
with good patient compliance. But the nonspecific distribution of the oral drugs may cause …

Oral delivery of biomacromolecules by overcoming biological barriers in the gastrointestinal tract: an update

S Liu, X Wen, X Zhang, S Mao - Expert opinion on drug delivery, 2023 - Taylor & Francis
Introduction Biomacromolecules have proven to be an attractive choice for treating diseases
due to their properties of strong specificity, high efficiency, and low toxicity. Besides greatly …

Two-photon excitation photosensitizers for photodynamic therapy: From small-molecules to nano-complex systems

V Juvekar, DJ Lee, TG Park, R Samanta… - Coordination Chemistry …, 2024 - Elsevier
Two-photon excitation photodynamic therapy (TP-PDT), which uses near-infrared light (>
700 nm) as an excitation source, is an essential approach for modern deep-tissue …

Injectable nanosized formulation for glucose-responsive insulin delivery

Y Wang, P Chen, W Liu, X Wei, J Zhang, X Wei, Y Liu… - Nano Today, 2023 - Elsevier
Glucose-responsive insulin (GRI) can tremendously facilitate insulin administration via
expanding the safe dosage window and reducing injection frequency, as well as enhancing …