The a 28-amino acid peptide ghrelin was discovered in 1999 as a growth hormone (GH)
releasing peptide. Soon after its discovery, ghrelin was found to increase body weight and …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Intensive efforts are focused on identifying regulators of human pancreatic islet cell growth
and maturation to accelerate development of therapies for diabetes. After birth, islet cell …

Seeking to assess the representative and instructive value of an engineered mouse model
of pancreatic neuroendocrine tumors (PanNET) for its cognate human cancer, we profiled …

Cellular identity is established by genetic, epigenetic, and environmental factors that
regulate organogenesis and tissue homeostasis. Although some flexibility in fate potential is …

Elucidation of cellular and gene regulatory networks (GRNs) governing organ development
will accelerate progress toward tissue replacement. Here, we have compiled reference …

Pancreatic islet β-cell insufficiency underlies pathogenesis of diabetes mellitus; thus,
functional β-cell replacement from renewable sources is the focus of intensive worldwide …

Many organs of higher organisms are heavily branched structures and arise by an
apparently similar process of branching morphogenesis. Yet the regulatory components and …

Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However,
spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging …

Delineating gene regulatory networks that orchestrate cell-type specification is a continuing
challenge for developmental biologists. Single-cell analyses offer opportunities to address …