Background: Obsessive-compulsive disorder (OCD) is a common and severe psychiatric
illness that affects 1–3% of the population and presents a well-established co-morbidity with …

Although our knowledge of the pathophysiology of schizophrenia has increased, treatments
for this devastating illness remain inadequate. Here, we critically assess rodent models and …

Pharmacologic blockade of monoamine oxidase A (MAOA) or serotonin transporter (5-HTT)
has antidepressant and anxiolytic efficacy in adulthood. Yet, genetically conferred MAOA or …

Identifying the genes that underlie the pathogenesis of chromosome deletion and
duplication syndromes is a challenge because the affected chromosomal segment can …

Choice impulsivity has been linked to dopamine function and is consistently observed in
attention deficit/hyperactivity disorder (ADHD) as a preference for smaller-immediate over …

Context Early-onset antisocial behavior accompanied by attention-deficit/hyperactivity
disorder is a clinically severe variant of antisocial behavior that is associated with a …

The catechol-O-methyltransferase (COMT) gene has attracted strong neuroscientific interest
due to its implication in dopaminergic neurotransmission. One of its most widely studied …

Considerable evidence suggests that multiple learning systems can drive behavior. Choice
can proceed reflexively from previous actions and their associated outcomes, as captured by …

BACKGROUND: Suicidal behavior is often correlated with other-directed aggression, which
is partially mediated by catecholaminergic neurotransmission. Catechol-O …

Catechol-O-methyl transferase (COMT) is a catabolic enzyme involved in the degradation of
a number of bioactive molecules; of principal interest to psychiatry, these include dopamine …