The purposes of this review are to assess the human exposure and human and
experimental evidence for adverse effects of brominated flame-retardants (BFRs) with …

Unrecognized congenital hypothyroidism leads to mental retardation. Newborn screening
and thyroid therapy started within 2 weeks of age can normalize cognitive development. The …

OBJECTIVES: To compare neurodevelopmental outcomes in severe and moderate
congenital hypothyroidism (CH) among 3 different initial L-thyroxine doses and to examine …

Thyroid hormones play important roles in brain development. The physiologic function of
thyroid hormones in the developing brain is to provide a timing signal that leads to the …

Congenital hypothyroidism (CH), usually of the primary and permanent variety, is an
eminently preventable cause of growth retardation and mental handicap whose outlook has …

Thyroid hormone (TH) plays a key role in mammalian brain development. The developing
brain is sensitive to both TH deficiency and excess. Brain development in the absence of TH …

Thyroid hormone (TH) may control the ratio of oligodendrocytes to astrocytes in white matter
by acting on a common precursor of these two cell types. If so, then TH should produce an …

Despite many physiological similarities, humans and rats exhibit notably different
susceptibilities to thyroid perturbation. Considerable research has recently been conducted …

Bioenergetics describe the biochemical processes responsible for energy supply in
organisms. When these changes become dysregulated in brain development, multiple …

Thyroid hormone insufficiency adversely affects cortical development; however, its effect on
apoptosis modulation during cerebral cortex development is not understood. We …