INTRODUCTION within countries the burden of NTDs is found among the poorest 40% of
households, as well as those living in rural or peri-urban areas (8). There are differences …

Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …

Genital Chlamydia trachomatis infection is the most commonly diagnosed sexually
transmitted infection. Trachoma is caused by ocular infection with C trachomatis and is the …

Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been
used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic …

Antibodies are unique among biomarkers in their ability to identify persons with protective
immunity to vaccine-preventable diseases and to measure past exposure to diverse …

Background Efforts are underway to eliminate trachoma as a public health problem by 2020.
Programmatic guidelines are based on clinical signs that correlate poorly with Chlamydia …

Background Serological antibody levels are a sensitive marker of pathogen exposure, and
advances in multiplex assays have created enormous potential for large-scale, integrated …

Background Serological surveys with multiplex bead assays can be used to assess
seroprevalence to multiple pathogens simultaneously. However, multiple methods have …

Background Programs seeking to eliminate the eye disease trachoma use prevalence of the
clinical sign trachomatous inflammation–follicular (TF) in 1-to 9-year-olds as a proxy for …

Background Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious
cause of blindness worldwide. Yearly azithromycin mass drug administration (MDA) plays a …