Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

Polycomb group proteins maintain the gene-expression pattern of different cells that is set
during early development by regulating chromatin structure. In mammals, two main …

Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin,
but how they target chromatin remains poorly understood. We have used chromatin RNA …

Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …

A key step in gene repression by Polycomb is trimethylation of histone H3 K27 by PCR2 to
form H3K27me3. H3K27me3 provides a binding surface for PRC1. We show that …

Abstract Polycomb group (PcG) and Trithorax group (TrxG) genes encode important
regulators of development and differentiation in metazoans. These two groups of genes …

Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …

Summary Polycomb-repressive complex 1 (PRC1) has a central role in the regulation of
heritable gene silencing during differentiation and development. PRC1 recruitment is …

Many studies have revealed pathways of epigenetic gene silencing by Polycomb repressive
complex 2 (PRC2) in vivo, but understanding the underlying molecular mechanisms …

Polycomb group (PcG) proteins are major determinants of gene silencing and epigenetic
memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome …