Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells

Y Zhang, R Tedja, M Millman, T Wong, A Fox… - Journal of Ovarian …, 2023 - Springer
Background Chromobox protein homolog 7 (CBX7), a member of the Polycomb repressor
complex, is a potent epigenetic regulator and gene silencer. Our group has previously …

Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells

R El Baba, S Haidar Ahmad, F Monnien, R Mansar… - Oncogene, 2023 - nature.com
Human cytomegalovirus (HCMV) infection has been implicated in epithelial ovarian cancer
(OC). Polyploidy giant cancer cells (PGCCs) have been observed in high-grade serous …

A Novel Role of Connective Tissue Growth Factor in the Regulation of the Epithelial Phenotype

RP Gogoi, S Galoforo, A Fox, C Morris, H Ramos… - Cancers, 2023 - mdpi.com
Simple Summary Cancer progression and metastasis is associated with the transformation
of epithelial cells into mesenchymal cells, a process known as epithelial–mesenchymal …

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

T Wong, R Tedja, H Chehade, R Morris… - JoVE (Journal of …, 2024 - jove.com
Ovarian cancer is the deadliest gynecologic malignancy. The omentum plays a key role in
providing a supportive microenvironment to metastatic ovarian cancer cells as well as …

Intricate Synergy of Mechanical and Biochemical Cues in the Transmigration of Cancer Cells Across the Endothelium

CT Mierke - 2024 - Springer
Mechanical stimuli such as forces, fluid shear stresses and pressures play a role in the
migration of cancer cells through the endothelial monolayer of blood vessels. In the …