With aging, the kidney undergoes inexorable and progressive changes in structural and
functional performance. These aging‐related alterations are more obvious and serious in …

Klotho is a novel renoprotective anti-aging protein available in membrane-bound or soluble
form. Klotho is expressed in brain, pancreas, and other solid organs but shows highest …

Recent studies have revealed critical roles of transforming growth factor-β1 (TGF-β1) and
microRNA-132 (miR-132), a downstream mediator of TGF-β1, in the pathogenesis of cardiac …

Albumin absorbed by renal tubular epithelial cells induces inflammation and plays a key role
in promoting diabetic kidney disease (DKD) progression. Macrophages are prominent …

Klotho, an antiaging protein, has been shown to play a protective role in renal tubular
epithelial-mesenchymal transition (EMT) during the development of diabetic kidney disease …

Diabetic nephropathy (DN) is a progressive disease, the main pathogeny of which is
podocyte injury. As a calcium-dependent serine/threonine protein kinase involved in …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and
is a significant burden on healthcare systems. α-klotho (klotho) is a protein known for its anti …

Diabetic nephropathy (DN) represents one of the most devastating complications for patients
with diabetes. The anti-diabetic activities of Magnoflorine (MF) were reported, with …

Background. NADPH oxidase 4 (NOX4) plays a major role in renal oxidative stress of
diabetic kidney disease (DKD). NOX4 was significantly increased in Egr1‐expressing …

Diabetic kidney disease (DKD) is one of the major microvascular complications of diabetes
mellitus, with relatively high morbidity and mortality globally but still in short therapeutic …