The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases

JA Adetunji, KD Fasae, AI Awe, OK Paimo… - Heliyon, 2023 - cell.com
The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier
separating the blood and the tissues in several organs. ECs maintain endothelium integrity …

Vascular organoids: unveiling advantages, applications, challenges, and disease modelling strategies

H Naderi-Meshkin, VA Cornelius… - Stem Cell Research & …, 2023 - Springer
Understanding mechanisms and manifestations of cardiovascular risk factors, including
diabetes, on vascular cells such as endothelial cells, pericytes, and vascular smooth muscle …

Vascularized adipose tissue engineering: moving towards soft tissue reconstruction

A Peirsman, HT Nguyen, M Van Waeyenberge… - …, 2023 - iopscience.iop.org
Soft tissue defects are a common clinical challenge mostly caused by trauma, congenital
anomalies and oncological surgery. Current soft tissue reconstruction options include …

A novel endothelial-related prognostic index by integrating single-cell and bulk RNA sequencing data for patients with kidney renal clear cell carcinoma

DX Li, QX Yu, CX Zeng, LX Ye, YQ Guo, JF Liu… - Frontiers in …, 2023 - frontiersin.org
Background: Endothelial cells in the tumor microenvironment play an important role in the
development of kidney renal clear cell carcinoma (KIRC). We wanted to further identify the …

Manufacturing the multiscale vascular hierarchy: progress toward solving the grand challenge of tissue engineering

EA Margolis, NE Friend, MW Rolle, E Alsberg… - Trends in …, 2023 - cell.com
In human vascular anatomy, blood flows from the heart to organs and tissues through a
hierarchical vascular tree, comprising large arteries that branch into arterioles and further …

Endothelial type I interferon response and brain diseases: identifying STING as a therapeutic target

N Duarte, AM Shafi, C Penha-Gonçalves… - Frontiers in Cell and …, 2023 - frontiersin.org
The endothelium layer lining the inner surface of blood vessels serves relevant
physiological functions in all body systems, including the exchanges between blood and …

Blood–Brain Barrier Breakdown in Neuroinflammation: Current In Vitro Models

S Brandl, M Reindl - International Journal of Molecular Sciences, 2023 - mdpi.com
The blood–brain barrier, which is formed by tightly interconnected microvascular endothelial
cells, separates the brain from the peripheral circulation. Together with other central nervous …

State-of-the-art advancements in liver-on-a-chip (LOC): integrated biosensors for LOC

M Liu, Y Xiang, Y Yang, X Long, Z Xiao, Y Nan… - Biosensors and …, 2022 - Elsevier
Liver models are vital for the liver diseases and drug research as many novel drugs.
However, traditional liver models cannot meet this need, mainly because they cannot …

Recent advancements and future requirements in vascularization of cortical organoids

E LaMontagne, AR Muotri, AJ Engler - Frontiers in Bioengineering …, 2022 - frontiersin.org
The fields of tissue engineering and disease modeling have become increasingly cognizant
of the need to create complex and mature structures in vitro to adequately mimic the in vivo …

Integration of immune cells in organs-on-chips: a tutorial

L Van Os, B Engelhardt, OT Guenat - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Viral and bacterial infections continue to pose significant challenges for numerous
individuals globally. To develop novel therapies to combat infections, more insight into the …