The endoplasmic reticulum (ER) as an intracellular Ca2+ store not only sets up cytosolic
Ca2+ signals, but, among other functions, also assembles and folds newly synthesized …

Introduction• Protein aggregation‐'Toxic oligomer'hypothesis‐Protein (mis) folding‐
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …

This review is focused on aging-related changes in cells and extracellular matrix of the
articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage …

Cardiovascular disease constitutes a major and increasing health burden in developed
countries. Although treatments have progressed, the development of novel treatments for …

Metaflammation, an atypical, metabolically induced, chronic low-grade inflammation, plays
an important role in the development of obesity, diabetes, and atherosclerosis. An important …

Osteoarthritis (OA) is the most prevalent joint disease, but neither preventive measures nor
disease-modifying drugs are available and a continuing need exists for safe and effective …

The endoplasmic reticulum (ER) plays a crucial role in protein folding, assembly, and
secretion. Disruption of ER homeostasis may lead to accumulation of misfolded or unfolded …

Rationale: Restoration of coronary artery blood flow is the most effective means of
ameliorating myocardial damage triggered by ischemic heart disease. However, coronary …

In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine
balance between anabolic and catabolic activities. In ageing, degenerative joint diseases …

Maintaining homeostasis of Ca 2+ stores in the endoplasmic reticulum (ER) is crucial for
proper Ca 2+ signaling and key cellular functions. The Ca 2+-release-activated Ca …