Maintenance therapy in AML: the past, the present and the future

M Molica, M Breccia, R Foa, E Jabbour… - American journal of …, 2019 - Wiley Online Library
Curative treatment in acute myeloid leukemia (AML) depends on successful induction
therapy to achieve a complete remission (CR), and subsequent post‐remission therapy to …

Application of machine learning in the management of acute myeloid leukemia: current practice and future prospects

JN Eckardt, M Bornhäuser, K Wendt… - Blood …, 2020 - ashpublications.org
Abstract Machine learning (ML) is rapidly emerging in several fields of cancer research. ML
algorithms can deal with vast amounts of medical data and provide a better understanding of …

[HTML][HTML] Nivolumab maintenance in high-risk acute myeloid leukemia patients: A single-arm, open-label, phase II study

PK Reville, HM Kantarjian, F Ravandi, E Jabbour… - Blood cancer …, 2021 - nature.com
Dear Editor, Patients with high-risk AML ineligible for allogeneic hematopoietic stem cell
transplantation (allo-SCT) have poor outcomes and low likelihood of cure 1. Maintenance …

[HTML][HTML] Successful application of PD-1 knockdown CLL-1 CAR-T therapy in two AML patients with post-transplant relapse and failure of anti-CD38 CAR-T cell …

YJ Ma, HP Dai, QY Cui, W Cui, WJ Zhu… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Patients with relapsed/refractory acute myeloid leukemia (R/R AML) often show resistance to
chemotherapy and have dismal outcomes. Therefore, it is urgent to develop new treatment …

Comparison of transplant outcomes between haploidentical transplantation and single cord blood transplantation in non‐remission acute myeloid leukaemia: A …

K Matsuda, T Konuma, K Fuse… - British Journal of …, 2023 - Wiley Online Library
Allogeneic haematopoietic stem cell transplantation (HSCT) is a potentially curative
treatment for some patients with acute myeloid leukaemia (AML) who are refractory to …

[HTML][HTML] Current therapeutic results and treatment options for older patients with relapsed acute myeloid leukemia

F Ferrara, F Lessi, O Vitagliano, E Birkenghi, G Rossi - Cancers, 2019 - mdpi.com
Considerable progress has been made in the treatment of acute myeloid leukemia (AML).
However, current therapeutic results are still unsatisfactory in untreated high-risk patients …

[HTML][HTML] Maintenance therapy in AML

PK Reville, TM Kadia - Frontiers in Oncology, 2021 - frontiersin.org
Recent advances in therapeutics coupled with steady improvements in supportive care for
patients with acute myeloid leukemia (AML) have led to improved outcomes. Despite these …

[HTML][HTML] Transcriptome profiling of N7-methylguanosine modification of messenger RNA in drug-resistant acute myeloid leukemia

B Zhang, D Li, R Wang - Frontiers in oncology, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is an aggressive hematological tumor caused by the
malignant transformation of myeloid progenitor cells. Although intensive chemotherapy …

Midostaurin plus daunorubicin or idarubicin for young and older adults with FLT3-mutated AML: a phase 3b trial

J Sierra, P Montesinos, X Thomas… - Blood …, 2023 - ashpublications.org
The pivotal RATIFY study demonstrated midostaurin (50 mg twice daily) with standard
chemotherapy significantly reduced mortality in adult patients (< 60 years) with newly …

[HTML][HTML] Dipetidyl peptidase-4 and transferrin receptor serve as prognostic biomarkers for acute myeloid leukemia

J Wei, GY Nai, Y Dai, XJ Huang, MY Xiong… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background Acute myeloid leukemia (AML) is the most common hematological malignancy
in adult patients. Ferroptosis-related signatures have been shown to act as regulators of the …