The introduction of serotonin 5-HT3 receptor antagonists into clinical practice allowed for a
dramatic improvement in the management of nausea and vomiting. Despite this …

Extensive efforts since 1931, on the structural determination of the mammalian tachykinin SP
by NMR, CD and IR have turned out to be inconclusive. Studies are now being concentrated …

After its discovery in 1931, substance P (SP) remained the only mammalian member of the
family of tachykinin peptides for several decades. Tachykinins thus refer to peptides sharing …

The present study characterizes the safety, pharmacokinetics, and anti‐emetic effects of the
selective NK‐1 receptor antagonist maropitant in the cat. Safety of maropitant was …

Cyclic analogues of N-[3, 5-bis (trifluoromethyl) benzyl]-7, 8-dihydro-N, 7-dimethyl-5-(4-
methylphenyl)-8-oxo-1, 7-naphthyridine-6-carboxamide (1) having a 6− 9-membered ring …

Hemokinin-1 (HK-1) is a recently described mouse tachykinin peptide whose biological
functions are not fully understood. To date, a unique receptor for HK-1 has not been …

The peptide substance P and its tachykinin receptor, neurokinin-1 (NK1), have been the
focus of considerable research for their role in a variety of both central and peripheral …

1. Introduction....................................................................... 2746 1.1. Jacobsen's HKR
procedure.................................................... 2747 1.2. Jacobsen's catalyst …

Neurokinin-1 (NK1) receptor antagonists have been reported to possess antidepressant and
anxiolytic properties in controlled trials. Since antidepressant and anxiolytic drugs act mainly …

A series of novel five-and six-membered ring urea derivatives have been described as
potent and selective NK1 receptor antagonists. Several compounds in this series exhibited …