Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis
and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the …

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been
modest. Physiologically, GF interactions with extracellular matrix (ECM) components …

The VEGF (vascular endothelial growth factor) family and its receptors are essential
regulators of angiogenesis and vascular permeability. Currently, the VEGF family consists of …

Vascular endothelial growth factor (VEGF) was originally identified as an endothelial cell
specific growth factor stimulating angiogenesis and vascular permeability. Some family …

Abstract Purpose: Axitinib (AG-013736) is a potent and selective inhibitor of vascular
endothelial growth factor (VEGF) receptor tyrosine kinases 1 to 3 that is in clinical …

Vascular endothelial cells are ordinarily quiescent in adult humans and divide less than
once per decade. When tumors reach a size of about 0.2–2.0 mm in diameter, they become …

Abstract ZD6474 [N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)
methoxy] quinazolin-4-amine] is a potent, po active, low molecular weight inhibitor of kinase …

The ability of tumor cells to escape tumor immunosurveillance contributes to cancer
development. Factors produced in the tumor microenvironment create “tolerizing” conditions …

Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel
development and homeostasis but also have profound effects on neural cells. VEGFs are …