Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications

MS Castaneto, DA Gorelick, NA Desrosiers… - Drug and alcohol …, 2014 - Elsevier
Background Synthetic cannabinoids (SC) are a heterogeneous group of compounds
developed to probe the endogenous cannabinoid system or as potential therapeutics …

Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals?

V Martínez, A Iriondo De-Hond, F Borrelli… - International Journal of …, 2020 - mdpi.com
Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used
for different purposes, like the production of fibers, the production of oil from the seeds, and …

Cannabinoid hyperemesis syndrome

JA Galli, R Andari Sawaya… - Current drug abuse …, 2011 - ingentaconnect.com
Coinciding with the increasing rates of cannabis abuse has been the recognition of a new
clinical condition known as Cannabinoid Hyperemesis Syndrome. Cannabinoid …

The Peripheral Cannabinoid Receptor Type 1 (CB1) as a Molecular Target for Modulating Body Weight in Man

SE O'Sullivan, AS Yates, RK Porter - Molecules, 2021 - mdpi.com
The cannabinoid 1 (CB1) receptor regulates appetite and body weight; however, unwanted
central side effects of both agonists (in wasting disorders) or antagonists (in obesity and …

Melatonin treatment alleviates spinal cord injury-induced gut dysbiosis in mice

Y Jing, D Yang, F Bai, C Zhang, C Qin, D Li… - Journal of …, 2019 - liebertpub.com
Spinal cord injury (SCI) disturbs the autonomic nervous system and induces dysfunction in
multiple organs/tissues, such as the gastrointestinal (GI) system. The neuroprotective effects …

Different receptor mechanisms underlying phytocannabinoid versus synthetic cannabinoidinduced tetrad effects: Opposite roles of CB1/CB2 versus GPR55 …

XF Wang, E Galaj, GH Bi, C Zhang, Y He… - British journal of …, 2020 - Wiley Online Library
Background and Purpose Cannabis or cannabinoids produce characteristic tetrad effects—
analgesia, hypothermia, catalepsy and suppressed locomotion, which are believed to be …

Cannabinoid hyperemesis syndrome: a review of potential mechanisms

MV DeVuono, LA Parker - Cannabis and Cannabinoid Research, 2020 - liebertpub.com
Introduction: Cannabinoids have long been known for their ability to treat nausea and
vomiting. Recent reports, however, have highlighted the paradoxical proemetic effects of …

Cannabinoid pharmacology and therapy in gut disorders

JA Uranga, G Vera, R Abalo - Biochemical Pharmacology, 2018 - Elsevier
Cannabis sp. and their products (marijuana, hashish…), in addition to their recreational,
industrial and other uses, have a long history for their use as a remedy for symptoms related …

Role of cannabinoids in gastrointestinal mucosal defense and inflammation

K Gyires, ZS Zádori - Current neuropharmacology, 2016 - ingentaconnect.com
Modulating the activity of the endocannabinoid system influences various gastrointestinal
physiological and pathophysiological processes, and cannabinoid receptors as well as …

Characterization of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy

G Vera, PA Cabezos, MI Martín, R Abalo - Pharmacology Biochemistry and …, 2013 - Elsevier
Clinical use of antineoplastic drugs is associated with the development of numerous
adverse effects that many patients find intolerable, including peripheral neuropathy …