p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics
Background Chronic obstructive pulmonary disease (COPD) is characterized by persistent
respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling …
respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling …
Eosinophilic inflammation: An appealing target for pharmacologic treatments in severe asthma
A Vatrella, A Maglio, C Pelaia, L Ciampo, G Pelaia… - Biomedicines, 2022 - mdpi.com
Severe asthma is characterized by different endotypes driven by complex pathologic
mechanisms. In most patients with both allergic and non-allergic asthma, predominant …
mechanisms. In most patients with both allergic and non-allergic asthma, predominant …
Insight into the pulmonary molecular toxicity of heated tobacco products using human bronchial and alveolar mucosa models at air–liquid interface
M Rahman, M Irmler, M Introna, J Beckers… - Scientific Reports, 2022 - nature.com
Heated tobacco products (HTP) are novel nicotine delivery products with limited
toxicological data. HTP uses heating instead of combustion to generate aerosol (HTP …
toxicological data. HTP uses heating instead of combustion to generate aerosol (HTP …
A computational approach identified andrographolide as a potential drug for suppressing COVID-19-induced cytokine storm
Background The newly identified betacoronavirus SARS-CoV-2 is the causative pathogen of
the coronavirus disease of 2019 (COVID-19) that killed more than 3.5 million people till now …
the coronavirus disease of 2019 (COVID-19) that killed more than 3.5 million people till now …
Revisiting asthma pharmacotherapy: where do we stand and where do we want to go?
M Cazzola, CP Page, MG Matera… - European …, 2023 - Eur Respiratory Soc
Several current guidelines/strategies outline a treatment approach to asthma, which
primarily consider the goals of improving lung function and quality of life and reducing …
primarily consider the goals of improving lung function and quality of life and reducing …
[HTML][HTML] Anti-inflammatory effect of chlorogenic acid in Klebsiella pneumoniae-induced pneumonia by inactivating the p38MAPK pathway
Y Zhang, C Zhu, H Zhao, Z Sun, X Wang - International Journal of Medical …, 2023 - Elsevier
Introduction Pneumonia is an inflammation-related respiratory infection and chlorogenic
acid (CGA) possesses a wide variety of bioactive properties, such as anti-inflammation and …
acid (CGA) possesses a wide variety of bioactive properties, such as anti-inflammation and …
Insights into potential mechanisms of asthma patients with COVID-19: A study based on the gene expression profiling of bronchoalveolar lavage fluid
Y Jiang, Q Yan, CX Liu, CW Peng, WJ Zheng… - Computers in Biology …, 2022 - Elsevier
Background The 2019 novel coronavirus disease (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a major challenge …
respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a major challenge …
[HTML][HTML] A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells
H Heo, Y Kim, B Cha, S Brito, H Kim, H Kim… - Journal of Ginseng …, 2023 - Elsevier
Background Hyperactivated airway mucosa cells overproduce mucin and cause severe
breathing complications. Here, we aimed to identify the effects of saponins derived from …
breathing complications. Here, we aimed to identify the effects of saponins derived from …
Targeting airway smooth muscle hypertrophy in asthma: An approach whose time has come
A Chetty, HC Nielsen - Journal of asthma and allergy, 2021 - Taylor & Francis
Airway smooth muscle (ASM) cell dysfunction is an important component of several
obstructive pulmonary diseases, particularly asthma. External stimuli such as allergens …
obstructive pulmonary diseases, particularly asthma. External stimuli such as allergens …
[HTML][HTML] DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD
Y Zhan, Q Huang, Z Deng, S Chen, R Yang… - Journal of Advanced …, 2024 - Elsevier
Introduction Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease
typically characterized by chronic airway inflammation, with emerging evidence highlighting …
typically characterized by chronic airway inflammation, with emerging evidence highlighting …