The neurobiology of irritable bowel syndrome

EA Mayer, HJ Ryu, RR Bhatt - Molecular psychiatry, 2023 - nature.com
Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that
affects between 5 and 10% of the general population worldwide. The current symptom …

Neuroinflammatory remodeling of the anterior cingulate cortex as a key driver of mood disorders in gastrointestinal disease and disorders

CE Matisz, AJ Gruber - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Most gastrointestinal diseases and disorders (GIDD) are associated with depression,
anxiety, and cognitive dysfunction. This suggests that shared features of GIDD, particularly …

A neuropsychosocial signature predicts longitudinal symptom changes in women with irritable bowel syndrome

RR Bhatt, A Gupta, JS Labus, C Liu, PP Vora… - Molecular …, 2022 - nature.com
Irritable bowel syndrome (IBS) is a common disorder of brain-gut interactions characterized
by chronic abdominal pain, altered bowel movements, often accompanied by somatic and …

Top-down cortical control of acute and chronic pain

L Urien, J Wang - Psychosomatic medicine, 2019 - journals.lww.com
Acute pain has an evolutionary role in the detection of physical harm and the response to it.
In some cases, however, acute pain can impair function and lead to other morbidities …

Brain structural alterations in MDD patients with gastrointestinal symptoms: evidence from the REST-meta-MDD project

P Liu, Y Li, AX Zhang, N Sun, GZ Li, X Chen… - Progress in Neuro …, 2021 - Elsevier
Objective While gastrointestinal (GI) symptoms are very common in patients with major
depressive disorder (MDD), few studies have investigated the neural basis behind these …

Chronic pain in children: structural and resting-state functional brain imaging within a developmental perspective

RR Bhatt, A Gupta, EA Mayer, LK Zeltzer - Pediatric research, 2020 - nature.com
Chronic pain is a major public health problem in the United States costing $635 billion
annually. Hospitalizations for chronic pain in childhood have increased almost tenfold in the …

Functional changes of default mode network and structural alterations of gray matter in patients with irritable bowel syndrome: a meta-analysis of whole-brain studies

M Zhao, Z Hao, M Li, H Xi, S Hu, J Wen… - Frontiers in …, 2023 - frontiersin.org
Background Irritable bowel syndrome (IBS) is a brain-gut disorder with high global
prevalence, resulting from abnormalities in brain connectivity of the default mode network …

Aberrant intraregional brain activity and functional connectivity in patients with diarrhea-predominant irritable bowel syndrome

XF Chen, Y Guo, XQ Lu, L Qi, KH Xu, Y Chen… - Frontiers in …, 2021 - frontiersin.org
Background and Purpose The appearance and aggravation of diarrhea-predominant
irritable bowel syndrome (IBS-D) have proven to be closely related to psychosocial factors …

[HTML][HTML] Altered brain structural connectivity in patients with longstanding gut inflammation is correlated with psychological symptoms and disease duration

J Turkiewicz, RR Bhatt, H Wang, P Vora, B Krause… - NeuroImage: Clinical, 2021 - Elsevier
Objective We aimed to identify differences in network properties of white matter
microstructure between asymptomatic ulcerative colitis (UC) participants who had a history …

[HTML][HTML] Default mode network connectivity is related to pain frequency and intensity in adolescents

SA Jones, AM Morales, AL Holley, AC Wilson… - NeuroImage: Clinical, 2020 - Elsevier
Pain during adolescence is common and is associated with future pain chronicity and
mental health in adulthood. However, understanding of the neural underpinnings of chronic …