The role and therapeutic implications of fibroblast‐like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis
EH Noss, MB Brenner - Immunological reviews, 2008 - Wiley Online Library
Fibroblast‐like synoviocytes (FLS) are resident mesenchymal cells of synovial joints that
have been recognized to play an increasingly important role in the pathogenesis of …
have been recognized to play an increasingly important role in the pathogenesis of …
The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis
S Sutton, A Clutterbuck, P Harris, T Gent, S Freeman… - The veterinary …, 2009 - Elsevier
Osteoarthritis (OA) is one of the most common and disabling chronic joint disorders affecting
horses, dogs and humans. Synovial inflammation or synovitis is a frequently observed …
horses, dogs and humans. Synovial inflammation or synovitis is a frequently observed …
[HTML][HTML] Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis
OBJECTIVE: C-reactive protein (CRP) has been associated with disease progression in
patients with osteoarthritis (OA), but the reasons for this remain unclear. We hypothesized …
patients with osteoarthritis (OA), but the reasons for this remain unclear. We hypothesized …
Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of …
S Orita, T Koshi, T Mitsuka, M Miyagi, G Inoue… - BMC musculoskeletal …, 2011 - Springer
Background One of the sources of knee pain in osteoarthritis (OA) is believed to be related
to local chronic inflammation of the knee joints, which involves the production of …
to local chronic inflammation of the knee joints, which involves the production of …
Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain
S Orita, T Ishikawa, M Miyagi, N Ochiai, G Inoue… - BMC musculoskeletal …, 2011 - Springer
Background The exact mechanism of knee osteoarthritis (OA)-associated pain is unclear,
whereas mixed evidence of inflammatory pain and neuropathic pain has been noted. We …
whereas mixed evidence of inflammatory pain and neuropathic pain has been noted. We …
Resveratrol suppresses interleukin-1β-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the …
M Shakibaei, C Csaki, S Nebrich… - Biochemical pharmacology, 2008 - Elsevier
Osteoarthritis is an inflammatory disease of load-bearing synovial joints that is currently
treated with drugs that exhibit numerous side effects and are only temporarily effective on …
treated with drugs that exhibit numerous side effects and are only temporarily effective on …
CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-α in TMJ osteoarthritis
H Zhu, Y Hu, C Wang, X Zhang, D He - Cell Death & Disease, 2020 - nature.com
Altered expression of circular RNAs (circRNAs) has been identified in various human
diseases. In this study, we investigated whether circRNAs function as competing …
diseases. In this study, we investigated whether circRNAs function as competing …
[HTML][HTML] Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs
M Pei, F He, BM Boyce, VL Kish - Osteoarthritis and Cartilage, 2009 - Elsevier
OBJECTIVE: Synovium-derived stem cells (SDSCs) have proven to be superior in cartilage
regeneration compared with other sources of mesenchymal stem cells. We hypothesized …
regeneration compared with other sources of mesenchymal stem cells. We hypothesized …
[HTML][HTML] Gene delivery of TGF-β1 induces arthrofibrosis and chondrometaplasia of synovium in vivo
RS Watson, E Gouze, PP Levings, ML Bush… - Laboratory …, 2010 - Elsevier
To understand the cellular and molecular events contributing to arthrofibrosis, we used an
adenovirus to deliver and overexpress transforming growth factor-beta 1 (TGF-β1) cDNA …
adenovirus to deliver and overexpress transforming growth factor-beta 1 (TGF-β1) cDNA …
Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1β-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by …
C Guo, L He, N Hu, X Zhao, L Gong, C Wang, C Peng… - Cytokine, 2022 - Elsevier
Background Fuzi lipid-soluble alkaloids (FLA) is the main bioactive components extracted
from the traditional Chinese medicine Aconiti Lateralis Radix Praeparata (“Fuzi” in Chinese) …
from the traditional Chinese medicine Aconiti Lateralis Radix Praeparata (“Fuzi” in Chinese) …