There is a critical need for reliable quantitative biomarkers to assess functional brain
alterations in mouse models of neuropsychiatric diseases, but current imaging methods …

Every study in rodents is also a behavioural genetic study even if only a single strain is used.
Outbred strains are genetically heterogeneous populations with a high intrastrain variation …

The great majority of acetylcholine effects in the central nervous system are mediated via
interaction with muscarinic cholinergic receptors. Muscarinic receptors were initially found to …

Apolipoprotein E (apoE) is involved in the risk to develop sporadic Alzheimer's disease (AD).
Since impaired central acetylcholine (ACh) function is a hallmark of AD, apoE may influence …

Anatomical evidence indicates that cholinergic and opioidergic systems are co-localized
and acting on the same neurons. However, the regulatory mechanisms between cholinergic …

J. Neurochem.(2011) 119, 89–99. Abstract Children exposed to methamphetamine during
brain development as a result of maternal drug use have long‐term hippocampus …

Publisher Summary This chapter reviews the evidence for genetic factors contributing to
variability in the functional, neurochemical, and neuroanatomical organization of the basal …

The binding of the muscarinic acetylcholine antagonist quimiclinidylbensilate to its specific
receptors was measured by quantitative autoradiography in the brain of the HPH‐5 mouse …

Congenital ornithine transcarbamylase (OTC) deficiency results in neuropathologic damage
to the cerebral cortex, basal ganglia, and thalamus. However, the precise nature of the cell …

This study demonstrates that a deficiency of forebrain cholinergic neurons occurs in
C57BL/6 (C57) mice, a strain characterized by poor learning capabilities. The brains of 21 …