The airway epithelium comprises of different cell types and acts as a physical barrier
preventing pathogens, including inhaled particles and microbes, from entering the lungs …

Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct
respiratory diseases that share features such as the obstruction of small airways and …

An overview of the application of natural and synthetic, non-viral vectors for oligonucleotide
delivery into the lung is presented in this review, with a special focus on lung cancer. Due to …

As a lipoxygenase (LOX), arachidonate 15-lipoxygenase type B (ALOX15B) peroxidizes
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …

Corticosteroid insensitivity is a key characteristic of patients with severe asthma and COPD.
These individuals experience greater pulmonary oxidative stress and inflammation, which …

The airway epithelial barrier is crucial for defending against respiratory insults and diseases.
Disruption of epithelial integrity contributes to respiratory diseases, and sex-specific …

Prolonged exposure to environmental respirable toxicants can lead to the development and
worsening of severe respiratory diseases such as asthma, chronic obstructive pulmonary …

The airway smooth muscle (ASM) surrounding the airways is dysfunctional in both asthma
and chronic obstructive pulmonary disease (COPD), exhibiting; increased contraction …

Background Epithelial damage, repair and remodelling are critical features of chronic airway
diseases including chronic obstructive pulmonary disease (COPD). Interleukin (IL)-33 …

Autophagy is the key process by which the cell degrades parts of itself within the lysosomes.
It maintains cell survival and homeostasis by removing molecules (particularly proteins) …