Microsatellite instability (MSI) is the molecular fingerprint of a deficient mismatch repair
system. Approximately 15% of colorectal cancers (CRC) display MSI owing either to …

Colorectal cancers (CRCs) with high microsatellite instability (MSI-H) and deficient mismatch
repair (dMMR) show molecular and clinicopathological characteristics that differ from those …

Cancer genomes from patients with African (AFR) ancestry have been poorly studied in
clinical research. We leverage two large genomic cohorts to investigate the relationship …

Recent evidence highlights the potential prognostic and predictive value of BRAF and K‐
RAS gene alterations in patients with colorectal cancer. However, a comprehensive …

Sporadic early onset colorectal carcinoma (EOCRC) which has by definition no identified
hereditary predisposition is a growing problem that remains poorly understood. Molecular …

Colorectal cancer is the second most common cause of cancer-related death in the United
States. Twin studies suggest that 35% of all colorectal cancer cases are inherited. High …

A MESSAGE FROM ASCO'S PRESIDENT As this report demonstrates—and as history
shows—investment in clinical cancer research pays off. Since 1990, cancer mortality rates …

Purpose To describe the frequency of MLH1 promoter methylation in colorectal cancer
(CRC); to explore the associations between MLH1 promoter methylation and …

Background: It is unknown if, after controlling for clinicopathologic variables and treatment,
racial disparities in colon cancer outcomes persist. Molecular marker analysis in North …

Over the past two decades, several protein and genomic markers have refined the
prognostic information of colorectal cancer (CRC) and helped to predict which patient group …