Quantitative MRI of Gd‐DOTA Accumulation in the Mouse Brain After Intraperitoneal Administration: Validation by Mass Spectrometry

A Tessier, AJ Ruze, I Varlet, EMH Laïb… - Journal of Magnetic …, 2023 - Wiley Online Library
Background In mice, intraperitoneal (ip) contrast agent (CA) administration is convenient for
mapping microvascular parameters over a long‐time window. However, continuous …

[HTML][HTML] Glymphatic-system function is associated with addiction and relapse in heroin dependents undergoing methadone maintenance treatment

L Wang, Y Qin, X Li, X Li, Y Liu, W Li, Y Wang - Brain Sciences, 2023 - mdpi.com
This study investigates the impact of methadone maintenance treatment (MMT) on the brain
glymphatic system (GS) in opioid addiction in China. A total of 51 male MMT patients, 48 …

[HTML][HTML] Assessing pulsatile waveforms of paravascular cerebrospinal fluid dynamics using dynamic diffusion-weighted imaging (dDWI)

Q Wen, Y Tong, X Zhou, M Dzemidzic, CY Ho… - Neuroimage, 2022 - ncbi.nlm.nih.gov
Cerebrospinal fluid (CSF) in the paravascular spaces of the surface arteries (sPVS) is a vital
pathway in brain waste clearance. Arterial pulsations may be the driving force of the …

Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the …

L Kelly, C Brown, D Michalik, CA Hawkes… - Alzheimer's & …, 2024 - Wiley Online Library
This editorial summarizes advances from the Clearance of Interstitial Fluid and
Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the …

FLUID study: study protocol for an open-label, single-centre pilot study to investigate the efFect of Lemborexant on sleep management in Japanese sUbjects aged 50 …

I Okada, K Iwamoto, S Miyata, A Fujimoto, M Tanaka… - BMJ open, 2021 - bmjopen.bmj.com
Introduction Bidirectional associations have been reported between sleep disturbance and
both cognitive impairment, including Alzheimer's disease and amyloid beta-peptide (Aβ) …

[HTML][HTML] Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies

SJ van Veluw, H Benveniste, ENTP Bakker… - Cellular and Molecular …, 2024 - Springer
The brain's network of perivascular channels for clearance of excess fluids and waste plays
a critical role in the pathogenesis of several neurodegenerative diseases including cerebral …

[HTML][HTML] Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain

M Segeroth, L Wachsmuth, M Gagel, F Albers… - Fluids and Barriers of …, 2023 - Springer
Background Despite recent attention, pathways and mechanisms of fluid transposition in the
brain are still a matter of intense discussion and driving forces underlying waste clearance in …

[HTML][HTML] Hypothermia impairs glymphatic drainage in traumatic brain injury as assessed by dynamic contrast-enhanced MRI with intrathecal contrast

W Gu, Y Bai, J Cai, H Mi, Y Bao, X Zhao, C Lu… - Frontiers in …, 2023 - frontiersin.org
Introduction The impact of hypothermia on the impaired drainage function of the glymphatic
system in traumatic brain injury (TBI) is not understood. Methods Male Sprague–Dawley rats …

Neurofluids—deep inspiration, cilia and preloading of the astrocytic network

HC Ludwig, S Dreha‐Kulaczewski… - Journal of …, 2021 - Wiley Online Library
With the advent of real‐time MRI, the motion and passage of cerebrospinal fluid can be
visualized without gating and exclusion of low‐frequency waves. This imaging modality …

[HTML][HTML] Visualizing fluid flows via regularized optimal mass transport with applications to neuroscience

X Chen, AP Tran, R Elkin, H Benveniste… - Journal of Scientific …, 2023 - Springer
The regularized optimal mass transport (rOMT) problem adds a diffusion term to the
continuity equation in the original dynamic formulation of the optimal mass transport (OMT) …