Understanding the basic principles of CNS fluid homeostasis including CSF physiology is
key to understanding brain health and neurodegenerative pathophysiology. The equilibrium …

类淋巴系统可以清除脑内代谢废物, 对维持中枢神经系统的内环境稳态起着重要作用, 是学习,
记忆等高级认知功能的重要基础. 近来, 越来越多的研究采用沿血管周围间隙弥散张量成像分析 …

Recent studies have suggested the glymphatic system as a solute transport pathway and
waste removal mechanism in the brain. Imaging intracisternally administered tracers …

The recent demonstration of brain waste clearance pathways, including the presence of
meningeal lymphatics, is fundamental in our understanding of neuroinflammatory and …

The population aged over 65 is growing fast worldwide, and is predicted to reach 1.5 billion
by the year 2050. In parallel, relentlessly progressive neurodegenerative diseases …

This review examines the complex relationship between sleep, the glymphatic system and
Alzheimer's disease (AD) pathogenesis. It explores recent work calling into question the …

The ability of the brain to “wash” itself has important implications for overall brain function
and health. A brief historical perspective highlighting seminal studies first describing …

Introduction Bidirectional associations have been reported between sleep disturbance and
both cognitive impairment, including Alzheimer's disease and amyloid beta-peptide (Aβ) …

Confidential: For Review Only Page 1 Confidential: For Review Only Size-Dependent
Transport of Cerebrospinal Fluid Tracers in Mouse Brain Observed by Dynamic Contrast-Enhanced …

Brain imaging is usually associated to non-invasive techniques that enable to unmask the
structure and functioning of the brain in preclinical models and in human. Techniques to do …