Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …

One type of RNA editing converts adenosines to inosines (A→ I editing) in double-stranded
RNA (dsRNA) substrates. A→ I RNA editing is mediated by adenosine deaminase acting on …

Alternative splicing of precursor mRNA is an essential mechanism to increase the
complexity of gene expression, and it plays an important role in cellular differentiation and …

Abstract microRNAs (miRNAs) are generated from long primary (pri-) RNA polymerase II
(Pol II)–derived transcripts by two RNase III processing reactions: Drosha cleavage of …

RNA editing is a cellular process that precisely alters nucleotide sequences, thus regulating
gene expression and generating protein diversity. Over 60% of human transcripts undergo …

The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II comprises
multiple tandem conserved heptapeptide repeats, unique to this eukaryotic RNA …

Much of the complex process of RNP biogenesis takes place at the gene cotranscriptionally.
The target for RNA binding and processing factors is, therefore, not a solitary RNA molecule …

In eukaryotes, nascent RNA transcripts undergo an intricate series of RNA processing steps
to achieve mRNA maturation. RNA editing and alternative splicing are two major RNA …

RNA editing by adenosine deamination fuels the generation of RNA and protein diversity in
eukaryotes, particularly in higher organisms. This includes the recoding of translated exons …

The accurate and thorough genome-wide detection of adenosine-to-inosine editing, a
biologically indispensable process, has proven challenging. Here, we present a discovery …