[HTML][HTML] Jak inhibitors reverse vitiligo in mice but do not deplete skin resident memory T cells

V Azzolino, L Zapata Jr, M Garg, M Gjoni… - The Journal of …, 2021 - ncbi.nlm.nih.gov
Vitiligo is an autoimmune skin disease presenting with distinct, patchy areas of
depigmentation that can appear anywhere on the body. These white patches occur when …

Tissue-resident memory T cells in the era of (Neo) adjuvant melanoma management

KR Plunkett, JD Armitage, AJ Inderjeeth… - Frontiers in …, 2022 - frontiersin.org
Tissue-resident memory T (TRM) cells have emerged as key players in the immune control
of melanoma. These specialized cells are identified by expression of tissue retention …

Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway

L Peng, Y Lu, Y Gu, B Liang, Y Li, H Li, Y Ke… - Pharmaceutical …, 2023 - Taylor & Francis
Context Vitiligo is a common skin disease with a complex pathogenesis, and so far, no
effective treatment is available. Lycium barbarum L.(Solanaceae) polysaccharide (LBP), the …

Immunometabolism in the pathogenesis of vitiligo

C Lyu, Y Sun - Frontiers in Immunology, 2022 - frontiersin.org
Vitiligo is a common depigmenting skin disorder characterized by the selective loss of
melanocytes. Autoimmunity, genetic, environmental, and biochemical etiology have been …

Tissue-resident memory T cells in skin diseases: a systematic review

T Emmanuel, J Mistegård, A Bregnhøj… - International Journal of …, 2021 - mdpi.com
In health, the non-recirculating nature and long-term persistence of tissue-resident memory
T cells (TRMs) in tissues protects against invading pathogens. In disease, pathogenic TRMs …

The IFN‐γ‐CXCL9/CXCL10‐CXCR3 axis in vitiligo: Pathological mechanism and treatment

H Liu, Y Wang, Q Le, J Tong… - European Journal of …, 2024 - Wiley Online Library
Vitiligo is a disease featuring distinct white patches that result from melanocyte destruction.
The overall pathogenesis of vitiligo remains to be elucidated. Nevertheless, considerable …

[HTML][HTML] Understanding of pathomechanisms and clinical practice for vitiligo

A Tanemura - Annals of Dermatology, 2023 - ncbi.nlm.nih.gov
Vitiligo is a disease caused by the acquired depletion of melanocytes and/or melanocyte
precursor cells in response to genetic and environmental factors, resulting in …

The delicate relation between melanocytes and skin immunity: a game of hide and seek

R Speeckaert, A Belpaire… - Pigment Cell & …, 2022 - Wiley Online Library
Melanocytes exhibit a complex and intriguing relationship with the skin immune response,
leading to several clinical conditions. In some disorders, inappropriate melanocyte …

Efficacy and safety of tacrolimus 0.1% for the treatment of facial vitiligo: a multicenter randomized, double-blinded, vehicle-controlled study

J Seneschal, A Duplaine, H Maillard, T Passeron… - Journal of Investigative …, 2021 - Elsevier
Background Topical calcineurin inhibitors are used off label in the treatment of vitiligo, and
there is a lack of placebo-controlled, blinded studies to support their use. Objective This …

Human regulatory T cells: understanding the role of tregs in select autoimmune skin diseases and post-transplant nonmelanoma skin cancers

NC Oparaugo, K Ouyang, NPN Nguyen… - International journal of …, 2023 - mdpi.com
Regulatory T cells (Tregs) play an important role in maintaining immune tolerance and
homeostasis by modulating how the immune system is activated. Several studies have …