Pharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide
S Lakshminrusimha, B Mathew, CL Leach - Seminars in perinatology, 2016 - Elsevier
Inhaled nitric oxide (iNO) is approved for use in persistent pulmonary hypertension of the
newborn (PPHN) but does not lead to sustained improvement in oxygenation in one-third of …
newborn (PPHN) but does not lead to sustained improvement in oxygenation in one-third of …
Tips and traps analyzing pediatric PK data
BJ Anderson, NHG Holford - Pediatric Anesthesia, 2011 - Wiley Online Library
Pharmacokinetic (PK) and pharmacodynamic (PD) modeling has elucidated aspects of
developmental pharmacology of value to the anesthetic community. The increasing …
developmental pharmacology of value to the anesthetic community. The increasing …
American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock
AL Davis, JA Carcillo, RK Aneja, AJ Deymann… - Critical care …, 2017 - journals.lww.com
Objectives: The American College of Critical Care Medicine provided 2002 and 2007
guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the …
guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the …
Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine
J Brierley, JA Carcillo, K Choong, T Cornell… - Critical care …, 2009 - journals.lww.com
Background: The Institute of Medicine calls for the use of clinical guidelines and practice
parameters to promote “best practices” and to improve patient outcomes. Objective: 2007 …
parameters to promote “best practices” and to improve patient outcomes. Objective: 2007 …
Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation
A Jain, M Sahni, A El-Khuffash, E Khadawardi… - The Journal of …, 2012 - Elsevier
OBJECTIVES: To investigate the value of targeted neonatal echocardiography (TnECHO) in
predicting cardiorespiratory instability after patent ductus arteriosus (PDA) ligation, and to …
predicting cardiorespiratory instability after patent ductus arteriosus (PDA) ligation, and to …
Pharmacology of milrinone in neonates with persistent pulmonary hypertension of the newborn and suboptimal response to inhaled nitric oxide
PJ McNamara, SP Shivananda, M Sahni… - Pediatric critical care …, 2013 - journals.lww.com
Objectives: Persistent pulmonary hypertension of the newborn is a common problem with
significant morbidity and mortality. Inhaled nitric oxide is the standard care, but up to 40% of …
significant morbidity and mortality. Inhaled nitric oxide is the standard care, but up to 40% of …
Facilitation of drug evaluation in children by population methods and modelling
M Tod, V Jullien, G Pons - Clinical pharmacokinetics, 2008 - Springer
The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …
populations, the latter being particularly heterogeneous. These differences in …
[HTML][HTML] Milrinone in congenital diaphragmatic hernia–a randomized pilot trial: study protocol, review of literature and survey of current practices
S Lakshminrusimha, M Keszler, H Kirpalani… - … health, neonatology and …, 2017 - Springer
Background Congenital diaphragmatic hernia (CDH) is commonly associated with
pulmonary hypoplasia and pulmonary hypertension (PH). PH associated with CDH (CDH …
pulmonary hypoplasia and pulmonary hypertension (PH). PH associated with CDH (CDH …
Randomized trial of milrinone versus placebo for prevention of low systemic blood flow in very preterm infants
M Paradisis, N Evans, M Kluckow, D Osborn - The Journal of pediatrics, 2009 - Elsevier
OBJECTIVE: To assess the effectiveness of early prophylactic milrinone versus placebo for
prevention of low systemic blood flow in high-risk preterm infants. STUDY DESIGN: Double …
prevention of low systemic blood flow in high-risk preterm infants. STUDY DESIGN: Double …
[HTML][HTML] Controversies in the identification and management of acute pulmonary hypertension in preterm neonates
It is increasingly recognized that the abnormal physiologic consequences of pulmonary
hypertension (PH) may contribute to poor cardiopulmonary health in premature babies …
hypertension (PH) may contribute to poor cardiopulmonary health in premature babies …