Bone homeostasis is a dynamic equilibrium state of bone formation and absorption,
ensuring skeletal development and repair. Bone immunity encompasses all aspects of the …

Adipokines are biologically active factors secreted by adipose tissue that act on local and
distant tissues through autocrine, paracrine, and endocrine mechanisms. However …

Irisin, a novel adipo-myokine with metabolic regulatory functions, exerts anti-inflammatory,
antioxidant, and anti-apoptotic actions that may confer protection against sepsis-induced …

Vascular calcification is a common accompanying pathological change in many chronic
diseases, which is caused by calcium deposition in the blood vessel wall and leads to …

Irisin, a myokine, is secreted by the movement of skeletal muscles. It plays an important role
in metabolic homeostasis, insulin resistance, anti-inflammation, oxidative stress, and bone …

The PTEN gene negatively regulates the oncogenic PI3K-AKT pathway by encoding a lipid
and protein phosphatase that dephosphorylates lipid phosphatidylinositol-3, 4, 5 …

Currently, treatment options for acute lung injury (ALI) are limited. Gypenoside XLIX (Gyp-
XLIX) is known for its anti-inflammatory properties, but there is a lack of extensive research …

Macrophage polarization is closely associated with the inflammatory processes involved in
the development and chemoresistance of colorectal cancer (CRC). M2 macrophages, the …

Resumo Background and Aims: The chronic inflammatory process in the adipose tissue
during obesity suggests constant polarization of classically activated macrophages (M1) and …